Abstract

The open innovation hub Digital Health and Patient Safety Platform (DHPSP) was recently established with the purpose to invigorate collaborative scientific research and the development of new digital products and personalized solutions aiming to improve human health and patient safety. In this study, we evaluated the effectiveness of a Twitter‐based campaign centered on using the hashtag #DHPSP to promote the visibility of the DHPSP initiative. Thus, tweets containing #DHPSP were monitored forfive weeks for the period 20.10.2020–24.11.2020 and were analyzed with Symplur Signals (social media analytics tool). In the study period, a total of 11,005 tweets containing #DHPSP were posted by 3020 Twitter users, generating 151,984,378 impressions. Analysis of the healthcare stakeholder‐identity of the Twitter users who used #DHPSP revealed that the most of participating user accounts belonged to individuals or doctors, with the top three user locations being the United States (501 users), the United Kingdom (155 users), and India (121 users). Analysis of co‐occurring hashtags and the full text of the posted tweets further revealed that the major themes of attention in the #DHPSP Twitter‐community were related to the coronavirus disease 2019 (COVID‐19), medicine and health, digital health technologies, and science communication in general. Overall, these results indicate that the #DHPSP initiative achieved high visibility and engaged a large body of Twitter users interested in the DHPSP focus area. Moreover, the conducted campaign resulted in an increase of DHPSP member enrollments and website visitors, and new scientific collaborations were formed. Thus, Twitter campaigns centered on a dedicated hashtag prove to be a highly efficient tool for visibility‐ promotion, which could be successfully utilized by healthcare‐related open innovation platforms or initiatives.

Abstract

Silybum Marianum, is a plant belonging to the family Asteraceae. For many centuries it has been useda natural remedy for many diseases like Liver and Biliary tract diseases. It is effective as an anti- oxidant and is used in a variety of diseases. This study was conducted to check the effects of Silybum Marianum on PARP protein (4UND protein).The Molecular Docking techniques was chosen to check the effects of different chemical constituentsof Silybum marianum on DNA damaging protein. For this purpose, different PARP inhibitor drugs were taken as standard. The Molecular Docking of the chemical constituents of Silybum marianum was performed using 4UND protein with the help of PyRx software along with BIOVIA Drug Discovery studio software. The result of molecular docking showed that some of the chemical constituent have higher binding affinity than standard PARP inhibitor drugs. 

Abstract

Oyster mushroom (Pleurotus ostreatus) is belong to the group of healthy foods, as they contain high levels of proteins, vitamins and different classes of compounds, it is discovered that oyster mushrooms could play a key role in maintaining good health. Oyster mushroom (Pleurotus sp.) Class Basidiomycetes and Family Agaricaceae are widely known as ‘dhingri’ in India. Pleurotus Ostreatus have several medicinal properties including;, antitumor, immune modulatory, antiinflammatory, anticancer, antigenotoxic, anti-arthritic, hypocholesterolaemic, antihyperglycaemic, antioxidant, antihypertensive, antiplatelet aggregating, antiviral and antimicrobial activities.. In this paper studied that effects of chemical constituents of oyster mushroom (Pleurotus sp.) on DNA damaging protein which analyzed its activity of PARP inhibiting or vice – versa. For this analysis we choose the molecular docking technique to check the effects of different chemical constituents of oyster mushroom (Pleurotus sp.) on DNA damaging protein and compare their results to PARP inhibitory drugs which taken as standard. We perform the molecular docking in between chemical constituents of oyster mushroom (Pleurotus sp.) and 4UND protein compare to performance of molecular docking in between standard PARP inhibitory drugs and 4UND protein with the help of PyRx and BIOVIA Discovery studio software. The analysis of molecular docking shows that some chemical constituents of oyster mushroom (Pleurotus sp.) having more binding affinity than standard PARP inhibitory drugs. The Rutin shows better binding affinity than PARP inhibitory drugs on the same protein.

Abstract

As a folk medicine and a nutraceutical rich source of nutrients, mushrooms have remained an integral part of traditional cuisines for centuries due to their beneficial health attributes. They are being studied extensively today to explain their chemical nature and mechanisms of action in biomedicine and nutraceuticals. As a macrofungus, mushrooms belong to the astounding kingdom of Fungi. Mushrooms have impressive health benefits, including antiviral, antibacterial, wound healing, anticancer, immunomodulating, antioxidant, hepatoprotective, anti-hypercholesterolemia, and anti-diabetic effects, etc., all have been reported throughout the world and have generated significant interest in even further research. Consequently, they can serve as functional foods, help with the treatment of health issues that are not in optimal states, and can reduce the risk of developing life-threatening conditions. It was found that mushrooms contained a variety of polysaccharides, proteins, lipids/fats, vitamins and minerals that contributed to their therapeutic effects.