Documents published in Scipedia

• Evaluation of Brain Signal Amplifier Circuit Performance by Polymer Biosensor in Portable Neurological Patient Monitoring System

  S. Pirayeshfar;, M. Asadollahi;, R. Rahimi;

  Current Neuropharmacology (2023). Pirayeshfar.S., Asadollahi.M., Rahimic. R. 2022, Evaluation of Brain Signal Amplifier Circuit Performance by Polymer Biosensor in Portable Neurological Patient Monitoring System. Current Neuropharmacology., 23(2). 201. 10.2174/1570159X20666220927093818

  
  

  Abstract

  Increasing the flexibility of electrodes by using flexible biocompatible biopolymer substrates as well as using conductive polymers with suitable electrical conductivity such as (PEDOT: PSS) instead of metallic base materials in the electrode channels has greatly contributed to this goal. But the next step is to increase the amplitude of the touched signal by the electrode in an amplifier circuit by suitable gain factor. Therefore, in the present study an electrical biosensor consisting of a 64-channel microelectrode with intra-structural amplification capability, external circuit precision for amplification of sensible brain signals on scale has been studied. Thereafter, the polymer biosensor to be integrated into a dry and portable monitoring system for monitoring neurologic disorders and identification of focal seizures symptoms e.g. in aura state for epilepsy. This has allowed by achieving a precise signal on scale even with a dry multichannel electrode, without no electrolyte gel between the surface of the electrode and the skin. Although, localization of the electrode is restricted, due to the importance of touching the prone signals in the frontal and partial lobes, it has been attempted to place the electrode on the frontal area to increase both signal sensibility and processing. Moreover, the error of muscle movements in frontal lobe is reduced by locating electrode in frontal-partial (FP) position to achieve a signal that overlapping both lobes to predicting seizure symptoms more accurately. This set-up has been successfully tested on patients, and along with the designed interface circuit, using an open-source oscillography application, signal touching has also been accomplished by an Android-based mobile phone.

  Abstract
  Increasing the flexibility of electrodes by using flexible biocompatible biopolymer substrates as well as using conductive polymers with suitable electrical conductivity such [...]

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• Investigation on the Effects of Using Lithium on Biochemical Factors of Urinary Beta-2 Microglobulin, Creatinine and Urea Serum in Chronic Bipolar Patients

  R. Rahimi;, Z. Nasiri;

  Pharmaceutics; Journal (2022). Rahimi, R.; Nasiri, Z; Momeni Shideh, S.R.; Investigation on the Effects of Using Lithium on Biochemical Factors of Urinary Beta-2 Microglobulin, Creatinine and Urea Serum in Chronic Bipolar Patients Pharmaceutics 2024, 16, 1827

  
  

  Abstract

  In this research, the effects of using lithium on biochemical factors of urinary beta-2 microglobulin, creatinine and urea serum in chronic bipolar patients hospitalized in Razi psychiatric center are investigated. For this purpose, random sampling method was used and among hospitalized patients in Tehran's Razi psychiatric center. Then 87 patients were selected and urinary beta-2 microglobulin tests by ELISA method, urea and blood serum by enzymatic method measured in 42 bipolar patients (including 18 females - 24 males) that using lithium and 45 bipolar patients (including 21 females - 24 males) that using drugs other than lithium. According to studies, lithium-treated bipolar patients have a substantially greater urine beta-2 microglobulin concentration than individuals who are not lithium-treated (Pvale> 0.028). The results demonstrated that the longer time of using lithium will cause higher amount of urinary beta-2 microglobulin secretion (Pval> 0.027). Also, the results showed that the value of creatinine and urea serum were not significantly different between two groups. Finally, it seems that urinary beta- 2 microglobulin is a better indicator than urea and creatinine serum to evaluate the side effects of primary kidney damages caused by lithium, and its main role in diagnosis of the disease requires further researches in this field.

  Abstract
  In this research, the effects of using lithium on biochemical factors of urinary beta-2 microglobulin, creatinine and urea serum in chronic bipolar patients hospitalized in [...]

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