Documents published in Scipedia

• Multiphysical modeling of soft-tissue stent interaction (Plenary Lecture)

  S. Reese, K. Manjunatha, J. Shi, M. Sesa, M. Behr, F. Vogt

  coupled2023.

  
  

  Abstract

  The efficacy of cardiological interventions, including the implantation of prostheses, is highly dependent on patient-specific immunohistology and can be enhanced with computational predictive tools. Therefore, an in silico replication of neointimal hyperplasia shall provide the necessary insights about the biochemical and cellular interactions within the vessel wall, and eventually address the risks of in-stent restenosis in a patient-specific manner. In this context, we set up a multiphysics framework considering key mediators of restenosis and couple them to a continuum mechanical vessel wall model. The governing set of coupled partial PDEs for the underlying mechanobiological system is solved via the finite element method and the results are compared to those obtained using a deep learning framework employing physics-informed neural networks (PINNs). Another interesting cardiological intervention-related problem is the maturation of tissue-engineered cardiovascular implants wherein the evolution of the collagen density affects the tissue’s mechanical behavior. The model we present allows us to predict the evolution of collagen density within textile-reinforced heart valves.

  Abstract
  The efficacy of cardiological interventions, including the implantation of prostheses, is highly dependent on patient-specific immunohistology and can be enhanced with computational [...]

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• A coupled multiphysics approach for modelling in-stent restenosis

  S. Reese, K. Manjunatha, M. Behr, F. Vogt

  eccomas2022.

  
  

  Abstract

  Drug-eluting stents were developed to counteract the severe restenosis observed after bare-metal stent implantation. The risk of restenosis still prevailed due to the inhibitory effect of the drug on endothelial healing. The current work focuses on extending a multiphysics-based modeling framework to include the effect of anti-inflammatory drugs embedded in the drugeluting stents. An additional advection-reaction-diffusion equation governing the drug transport is introduced herein. Additionally, the effect of drugs, specifically rapamycin-based ones, on the proliferation of smooth muscle cells is captured. An optimal level of drug embedment is realized through the modeling framework.

  Abstract
  Drug-eluting stents were developed to counteract the severe restenosis observed after bare-metal stent implantation. The risk of restenosis still prevailed due to the inhibitory [...]

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