V. Carvalho, N. Rodrigues, R. Rodrigues, M. Bañobre, R. Lima, S. Teixeira
Organ-on-a-chip (OoC) platforms have revolutionized the drug development process by offering an effective alternative to animal models. These advanced microfluidic platforms mimic the organ functions at a microscale, and they can be produced at a large scale and at a lower price. Despite the variety of OoC models developed up to now, the combination of numerical simulations with experimental procedures has been of paramount importance in the development of more realistic and effective OoC devices. In addition, a better understanding of the physical phenomena happening in OoC can be obtained. In the present work, fluid flow numerical simulations were carried out in an OoC aiming to evaluate the influence of imposing different inlet velocities on the oxygen distribution along the device. This is of great importance to understand if the oxygen that reaches the cells is adequate for their culture. The results showed that for the geometry tested, with four organ models in parallel, by increasing the inlet velocity, the dissolved oxygen where cells are cultured also increases. This proves the importance of using numerical simulations for improving the performance of the experimental tests and optimizing the flow conditions.
Published on 02/01/23
DOI: 10.23967/eccomas.2023.001Licence: CC BY-NC-SA license
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