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== Abstract ==
 
== Abstract ==
  
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El objetivo de este trabajo es modelar y simular la contracción del corazón fetal a lo largo del ciclo cardíaco con el objetivo de entender la biomecánica del mismo, con ello se pretende ayudar a comprender los factores mecánicos que pueden contribuir a la aparición de malformaciones congénitas durante la gestación. Para ello se ha desarrollado un modelo 3D de elementos finitos de un corazón fetal de 23 semanas a partir de imágenes tomadas de fotografiaas y datos experimentales de orientación de fibras de medidas post-mortem de un corazón fetal humano. Para el modelado de las propiedades mecánicas es necesario utilizar un modelo hiperelástico fibrado que incorpora la activación muscular como un término añadido a la función densidad de energía de deformación. A partir de la simulación numérica se obtiene la distribución de deformaciones y tensiones a lo largo de la pared del miocardio y se compara la cinemática y el volumen eyectado con resultados experimentales. Para muchos autores estas variables son algunos de las factores de los que depende el crecimiento de la pared durante la gestación y, por tanto, estos resultados pueden ayudar a una mejor compresión del crecimiento y evolución del corazón fetal. Summary The purpose of this research is to study the fetal heart biomechanics during cardiac cycle. A 3D FEM of the human fetal heart (FH) is built by using the geometry and the ¯ber orientation measurements of a post-mortem FH. An anisotropic hyperelastic constitutive law describing the mechanical properties of the active myocardium is used. Kinematics of the heart and ejection fraction predicted by the model are compared with experimental observations. Our model can quantify the transmural distribution of strains and stresses during the cardiac cycle. Several authors supported the idea that fetal growth depends on the mean wall stress averaged through the space and during the cardiac cycle. For this reason, the results obtained in this work can be relevant in order to better understand the human FH growth process.
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The purpose of this research is to study the fetal heart biomechanics during cardiac cycle. A 3D FEM of the human fetal heart (FH) is built by using the geometry and the ¯ber orientation measurements of a post-mortem FH. An anisotropic hyperelastic constitutive law describing the mechanical properties of the active myocardium is used. Kinematics of the heart and ejection fraction predicted by the model are compared with experimental observations. Our model can quantify the transmural distribution of strains and stresses during the cardiac cycle. Several authors supported the idea that fetal growth depends on the mean wall stress averaged through the space and during the cardiac cycle. For this reason, the results obtained in this work can be relevant in order to better understand the human FH growth process.
  
 
== Full document ==
 
== Full document ==
 
<pdf>Media:draft_Content_460658718RR262D.pdf</pdf>
 
<pdf>Media:draft_Content_460658718RR262D.pdf</pdf>

Latest revision as of 11:01, 14 June 2017

Abstract

The purpose of this research is to study the fetal heart biomechanics during cardiac cycle. A 3D FEM of the human fetal heart (FH) is built by using the geometry and the ¯ber orientation measurements of a post-mortem FH. An anisotropic hyperelastic constitutive law describing the mechanical properties of the active myocardium is used. Kinematics of the heart and ejection fraction predicted by the model are compared with experimental observations. Our model can quantify the transmural distribution of strains and stresses during the cardiac cycle. Several authors supported the idea that fetal growth depends on the mean wall stress averaged through the space and during the cardiac cycle. For this reason, the results obtained in this work can be relevant in order to better understand the human FH growth process.

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Published on 01/04/10
Accepted on 01/04/10
Submitted on 01/04/10

Volume 26, Issue 2, 2010
Licence: CC BY-NC-SA license

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