Caffeine and sleep: Molecular and electrophysiological characteristics

Abstract

Caffeine is one of the most consumed stimulants in the world, being available in beverages such as coffee, chocolate, tea and energizers. It is a molecule used at the pharmacological level as an analgesic and causes psychostimulant effects related to decreased sleepiness, increased attention, modulation of memory and cognitive performance; In addition, it is recognized for the improvement of sports performance, among others (1).

The relationship between sleep and caffeine has been widely investigated, it has been established that this methylxanthine can prolong sleep latency, generate less total sleep time with decreased deep sleep and a parallel increase in light sleep (2).

Then, a review is presented that addresses the effect of caffeine on the polysomnographic stages of sleep and on the biological interactions that this substance presents in the adenosine receptors to which it joins; In addition, the genetic variations of these receptors will be taken into account, as possible causes of the changes induced by caffeine in sleep.

Keywords:

Sleep
caffeine
adenosine
adenosine receptor
ADORA2A
electroencephalography
genetic variations

How to cite

L. Castaño Loaiza, Caffeine and sleep: Molecular and electrophysiological characteristics, Collection of Articles on Biochemistry, Genetics and Molecular Biology (2019). 2 URL https://www.scipedia.com/public/Castano_Loaiza_2019a

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