Performance of stochastic restricted and unrestricted two-parameter estimators in linear mixed models

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==Performance of Stochastic Restricted and Unrestricted Two-Parameter Estimators in linear Mixed Models==

'''Nahid Ganjealivand<sup>*1</sup>, Fatemeh Ghapani<sup>2</sup>,'''<big>''' '''</big>'''Ali Zaherzadeh<sup>3</sup>, Farshin Hormozinejad<sup>1</sup>'''

<sup>1</sup> Department of Statistics, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran

ganjealivandsci[mailto:@ @]gmail.com

<sup>2</sup> Department of Mathematics and Statistics, Shoushtar Branch, Islamic Azad University, Shoushtar, Iran

∗Corresponding author. Email address:f.ghapani[mailto:sci@gmail.com sci@gmail.com], [mailto:f-ghapani@phdstu.ac.ir f-ghapani@phdstu.ac.ir]

<sup>3</sup>Jundi-Shapur University of Technology,Dezful,Iran
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==Abstract==

In this article, two parameter estimation using penalized likelihood method in the linear mixed model is proposed. In addition, by considering the stochastic linear restriction for the vector of fixed effects parameters we are introduced the stochastic restricted two parameter estimation. Methods are proposed for estimating variance parameters when unknown. Also, the superiority conditions of the two parameter estimator over the best linear unbiased estimator, and the stochastic restricted two parameter estimator over the stochastic restricted best linear unbiased estimator are obtained under the mean square error matrix sense. Methods are proposed for estimating of the biasing parameters. Finally, a simulation study and a numerical example are given to evaluate the proposed estimators.

'''Keywords''': Linear mixed model, two parameter estimation, stochastic restricted two parameter estimation, matrix mean square error.

<!--'''Mathematics Subject''' '''Classification'''  62J05. 62J12.-->
==1. Introduction==

Today many datasets lack the assumption of data independence, which is the main presupposition of many statistical models. For example data collected by cluster or hierarchical sampling, lengthwise studies and frequent measurements or in medical research that simultaneously provides data from one or more body members, the assumption of data independence is unacceptable because the data of a cluster, a group, or an individual are interdependent over time [1]. The default requirement for fitting linear models is the assumption of data independence that does not exist so the use of these models although it leads to unbiased estimates but the variance of estimating coefficients is strongly influenced by the default of data independence. In other words if the data are not independent then the standard error and therefore the confidence interval and the result test result will be for non-trust regression coefficients. Therefore in analyzing these data it is necessary to use methods that can consider this dependence. One of the most important ways to solve this problem is linear mixed models which are generalizations of simple linear models that provide the possibility of random and fixed effects with each other. Linear mixed models are used in many fields of physical, biological, medical and social sciences [2-5].

We consider the linear mixed model (LMM) as follows:

{| class="formulaSCP" style="width: 100%; text-align: center;" 
|-
| 
{| style="text-align: center; margin:auto;" 
|-
| style="text-align: center;" |<math display="inline">y=X\beta +Zu+\epsilon</math>
|-
| style="text-align: center;" |<math display="inline">q=\displaystyle\sum _{i=1}^{b}{q}_{i}</math>,
|}
| style="width: 5px;text-align: right;white-space: nowrap;" | (1)
|}

where <math display="inline">y</math> is an <math display="inline">n\times 1</math> vector of observations, <math display="inline">\mathit{\boldsymbol{Z}}=</math><math>\left[ {\mathit{\boldsymbol{Z}}}_{1},\ldots ,{\mathit{\boldsymbol{Z}}}_{b}\right]</math>  with <math display="inline">{\mathit{\boldsymbol{Z}}}_{i}</math> is an <math display="inline">n\times {q}_{i}</math> design matrix corresponding to the <math display="inline">i</math>-th random effects factor and <math display="inline">q</math>, <math display="inline">{q}_{i},\, X</math> is an <math display="inline">n\times p</math> observed design matrix for the fixed effects, <math display="inline">\beta</math>  is a <math display="inline">p\times 1</math> parameter vector of unknown fixed effects, <math display="inline">\mathit{\boldsymbol{u}}={\left[ {\mathit{\boldsymbol{u}}}_{1}^{'},\ldots ,{\mathit{\boldsymbol{u}}}_{b}^{'}\right] }^{'}</math> is a <math display="inline">q\times 1</math> unobservable vector of random effects and <math display="inline">\mathit{\boldsymbol{\epsilon }}</math> is an <math display="inline">n\times 1</math> unobservable vector of random errors. <math display="inline">u</math> and <math display="inline">\epsilon</math>  are independent and have a multivariate normal distribution as

{| class="formulaSCP" style="width: 100%; text-align: center;" 
|-
| <math>\left[ \begin{matrix}u\\\epsilon \end{matrix}\right] \sim \left( \left[ \begin{matrix}0\\0\end{matrix}\right] ,{\sigma }^{2}\left[ \begin{matrix}\mathit{\boldsymbol{G}}(\zeta )&0\\0&W(\xi )\end{matrix}\right] \right)</math> 
|}


where <math display="inline">\zeta</math>  and <math display="inline">\xi</math>  are <math display="inline">{r}_{1}\times 1</math> and <math display="inline">{r}_{2}\times 1</math> vectors of variance parameters corresponding to <math display="inline">u</math> and <math display="inline">\epsilon</math>, respectively. Henderson et al [6-7] introduced the set of equations called mixed model equations, and obtained <math display="inline">\tilde{\mathit{\boldsymbol{\beta }}}</math> and <math display="inline">\tilde{\mathit{\boldsymbol{u}}}</math> as
{| class="formulaSCP" style="width: 100%; text-align: center;" 
|-
| <math>\tilde{\mathit{\boldsymbol{\beta }}}={\left( {\mathit{\boldsymbol{X}}}^{'}{\mathit{\boldsymbol{H}}}^{-1}\mathit{\boldsymbol{X}}\right) }^{-1}{\mathit{\boldsymbol{X}}}^{'}{\mathit{\boldsymbol{H}}}^{-1}\mathit{\boldsymbol{y}}</math>
|}
{|class="formulaSCP" style="width: 100%; text-align: center;" 
|-
| <math>\left. \tilde{\mathit{\boldsymbol{u}}}=\mathit{\boldsymbol{G}}{\mathit{\boldsymbol{Z}}}^{'}{\mathit{\boldsymbol{H}}}^{-1}(\mathit{\boldsymbol{y}}- \mathit{\boldsymbol{X}}\tilde{\mathit{\boldsymbol{\beta }}})\right)</math>
|}

where <math display="inline">\mathrm{Var}\,(\mathit{\boldsymbol{y}})={\sigma }^{2}\mathit{\boldsymbol{H}}</math> and <math display="inline">\mathit{\boldsymbol{H}}=</math><math>\mathit{\boldsymbol{ZG}}{\mathit{\boldsymbol{Z}}}^{'}+\mathit{\boldsymbol{W}}</math>. They <math display="inline">\tilde{\mathit{\boldsymbol{\beta }}}</math> and <math display="inline">\tilde{\mathit{\boldsymbol{u}}}</math> are called the best linear unbiased estimator (BLUE) and the best linear unbiased predictor (BLUP), respectively. One of the most common estimators in linear regression is the ordinary least squares (OLS) estimator, which in the case of multicollinearity may lead to estimates with adverse effects such as high variance [8]. To reduce the effects of multicollinearity. Liu et al. [9-10] proposed the ridge estimator and the Liu estimator respectively, which are the well-known alternatives of the OLS estimator. Yang and Chang [11] obtained the two parameter estimator <math display="inline">\overset{\mbox{ˆ}}{\mathit{\boldsymbol{\beta }}}(k,d),</math> “Using the mixed estimation technique introduced by Theil et al. [12-13]. They considered the prior information about <math display="inline">\mathit{\boldsymbol{\beta }}</math> in the form of restriction as <math display="inline">(d-</math><math>k)\overset{\mbox{ˆ}}{\mathit{\boldsymbol{\beta }}}(k)=\mathit{\boldsymbol{\beta }}+</math><math>{\mathit{\boldsymbol{\epsilon }}}_{0},</math> where <math display="inline">k,d</math> and <math display="inline">\overset{\mbox{ˆ}}{\mathit{\boldsymbol{\beta }}}(k)</math> are respectively the ridge, Liu parameters and the ridge estimator”.

In <math display="inline">LMM</math>, authors such as Gilmour, Jiang and Searl in [14-16], considered a state where the matrix <math display="inline">{X}^{'}{H}^{-1}X</math> is singular. Liu and Hu [10] and Eliot et al. [17] inquired the ridge prediction in LMM. Liu and Hu [10] are obtained <math display="inline">\tilde{\mathit{\boldsymbol{\beta }}}(k)</math> and <math display="inline">\tilde{\mathit{\boldsymbol{u}}}(k)</math> as

{| class="formulaSCP" style="width: 100%; text-align: center;" 
|-
| <math>\tilde{\mathit{\boldsymbol{\beta }}}(k)={\left( {\mathit{\boldsymbol{X}}}^{'}{\mathit{\boldsymbol{H}}}^{-1}\mathit{\boldsymbol{X}}+k{\mathit{\boldsymbol{I}}}_{p}\right) }^{-1}\mathit{\boldsymbol{X}}{\mathit{\boldsymbol{H}}}^{-1}\mathit{\boldsymbol{y}}</math>
|}
{|class="formulaSCP" style="width: 100%; text-align: center;" 
|-
| <math>\tilde{u}(k)=G{Z}^{'}{H}^{-1}(y-X\tilde{\beta }(k))</math>
|}

where <math display="inline">\tilde{\mathit{\boldsymbol{\beta }}}(k)</math> and <math display="inline">\tilde{\mathit{\boldsymbol{u}}}(k)</math> are the ridge estimator of <math display="inline">\mathit{\boldsymbol{\beta }}</math> and the ridge predictor of <math display="inline">\mathit{\boldsymbol{u}},</math> respectively. Qzkale and Can [18] gave “an example from kidney failure data” to evaluate ridge estimator in linear mixed model. Kuran and Ozkale [19] obtained the mixed and stochastic restricted ridge predictors by using Gilmour approach. They introduced “stochastic linear restriction as <math display="inline">r=</math><math>R\beta +\Phi</math> where <math display="inline">r</math> is an <math display="inline">m\times 1</math> vector, <math display="inline">\mathit{\boldsymbol{R}}</math> is an <math display="inline">m\times p</math> known matrix of rank <math display="inline">m\leq p</math> and <math display="inline">\Phi</math>  is an <math display="inline">m\times 1</math> random vector that is assumed to be distributed with <math display="inline">E(\Phi )=</math><math>0</math> and <math display="inline">\mathrm{Var}\,(\Phi )={\sigma }^{2}\mathit{\boldsymbol{V}}(\mathit{\boldsymbol{v}}),</math> where <math display="inline">v</math> is <math display="inline">v\times 1</math> vector of variance parameters corresponding to <math display="inline">\Phi .</math> Also <math display="inline">\Phi</math>  and <math display="inline">\epsilon</math>  are independent”

Then derived the stochastic restricted estimator of <math display="inline">\beta</math>  and the stochastic restricted predictor of <math display="inline">\mathit{\boldsymbol{u}}</math> respectively, as

{| class="formulaSCP" style="width: 100%; text-align: center;" 
|-
| <math>{\tilde{\mathit{\boldsymbol{\beta }}}}_{r}={\left( {\mathit{\boldsymbol{X}}}^{'}{\mathit{\boldsymbol{H}}}^{-1}\mathit{\boldsymbol{X}}+{\mathit{\boldsymbol{R}}}^{'}{\mathit{\boldsymbol{V}}}^{-1}\mathit{\boldsymbol{R}}\right) }^{-1}\left( {\mathit{\boldsymbol{X}}}^{'}{\mathit{\boldsymbol{H}}}^{-1}\mathit{\boldsymbol{y}}+\right. </math><math>\left. {\mathit{\boldsymbol{R}}}^{'}{\mathit{\boldsymbol{V}}}^{-1}\mathit{\boldsymbol{r}}\right)</math> 
|}
{|class="formulaSCP" style="width: 100%; text-align: center;" 
|-
| <math>{\tilde{u}}_{r}=G{Z}^{'}{H}^{-1}\left( y-X{\tilde{\beta }}_{r}\right) </math>
|}

Furthermore, they obtained the stochastic restricted ridge estimator of <math display="inline">\beta</math>  and the stochastic restricted ridge predictor of <math display="inline">\mathit{\boldsymbol{u}}</math> respectively, as
{| class="formulaSCP" style="width: 100%; text-align: center;" 
|-
| <math>\tilde{\mathit{\boldsymbol{\beta }}},(k)={\left( {\mathit{\boldsymbol{X}}}^{'}{\mathit{\boldsymbol{H}}}^{-1}\mathit{\boldsymbol{X}}+{\mathit{\boldsymbol{R}}}^{'}{\mathit{\boldsymbol{V}}}^{-1}\mathit{\boldsymbol{R}}+{\mathit{\boldsymbol{H}}}_{p}\right) }^{-1}\left( {\mathit{\boldsymbol{X}}}^{'}{\mathit{\boldsymbol{H}}}^{-1}\mathit{\boldsymbol{y}}+ {\mathit{\boldsymbol{R}}}^{'}{\mathit{\boldsymbol{V}}}^{-1}\mathit{\boldsymbol{r}}\right)</math> 
|}
{|class="formulaSCP" style="width: 100%; text-align: center;" 
|-
| <math>{\tilde{\mathit{\boldsymbol{u}}}}_{r}(k)=\mathit{\boldsymbol{G}}{\mathit{\boldsymbol{Z}}}^{'}{\mathit{\boldsymbol{H}}}^{-1}\left( \mathit{\boldsymbol{y}}- \mathit{\boldsymbol{X}}{\tilde{\mathit{\boldsymbol{\beta }}}}_{r}(k)\right) </math>
|}

In this article, we obtain the new two parameter estimations in linear mixed models by taking Yang and Chang’s ideas [11] and considering restriction <math display="inline">(d-</math><math>k)\tilde{\beta }(k)=\beta +{\epsilon }_{0}.</math> In Section <math display="inline">2,</math> we follow the idea of Henderson’s mixed model equations to get the two parameter estimator. Then, by setting stochastic linear restrictions <math display="inline">r=</math><math>R\beta +\Phi</math>  on the vector of fixed effects parameters, we derive the stochastic restricted two parameter estimation. In Section 3, estimates for the variance parameters are obtained when unknown. In Section 4, under the mean square error matrix (MSEM) sense we offer comparisons of new two parameter estimators. In Section 5, Methods are proposed for estimating of the biasing parameters. In Sections 6 and 7, a simulation study and a real data analysis is given. Finally, summary and some conclusions are given in Section 8.

==2. The proposed estimators==

Under model (1), we have
{| class="formulaSCP" style="width: 100%; text-align: center;" 
|-
| <math>\left[ \begin{matrix}u\\y\end{matrix}\right] \sim N\left( \left[ \begin{matrix}0\\X\mathit{\boldsymbol{\beta }}\end{matrix}\right] ,{\sigma }^{2}\left[ \begin{matrix}G&G{Z}^{'}\\ZG&H\end{matrix}\right] \right)</math> 
|}

and the joint distribution of <math display="inline">u</math> and <math display="inline">y</math> is given by
{| class="formulaSCP" style="width: 100%; text-align: center;" 
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| <math>h(\mathit{\boldsymbol{y}},\mathit{\boldsymbol{u}})=h(\mathit{\boldsymbol{y}}\mid \mathit{\boldsymbol{u}})h(\mathit{\boldsymbol{u}})=</math><math>\frac{\mathrm{exp}\,\left\{ \frac{-1}{2{\sigma }^{2}}\left( (\mathit{\boldsymbol{y}}-\mathit{\boldsymbol{X\beta }}-\mathit{\boldsymbol{Zu}}{)}^{'}{\mathit{\boldsymbol{W}}}^{-1}(\mathit{\boldsymbol{y}}-\mathit{\boldsymbol{X\beta }}-\mathit{\boldsymbol{Zu}})+{\mathit{\boldsymbol{u}}}^{'}{\mathit{\boldsymbol{G}}}^{-1}\mathit{\boldsymbol{u}}\right) \right\} }{{\left. {\left( 2\pi {\sigma }^{2}\right) }^{(n+q)/2}\mathit{\boldsymbol{W}}\right| }^{1/2}\vert \mathit{\boldsymbol{G}}{\vert }^{1/2}}</math>
|}

where <math display="inline">G</math> and <math display="inline">W</math> are nonsingular. If the restriction used by Yang and Ghang [11] in linear regression is transferred to linear mixed model, we can produce the two parameter estimator using “penalized term” idea. So by unifying restriction <math display="inline">(d-</math><math>k)\tilde{\beta }(k)=\beta +{\epsilon }_{0}</math> with model (1) to give

{| class="formulaSCP" style="width: 100%; text-align: center;" 
|-
| 
{| style="text-align: center; margin:auto;" 
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| <math display="inline">{y}_{\ast }={X}_{\ast }+{Z}_{\ast }u+{\epsilon }_{\ast }</math>
|}
| style="width: 5px;text-align: right;white-space: nowrap;" | (2)
|}

where 
{| class="formulaSCP" style="width: 100%; text-align: center;" 
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| 
{| style="text-align: center; margin:auto;" 
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| <math>{\epsilon }_{0}\sim N\left( 0,{I}_{\ast }\right)</math>
|}
|}
with

{| class="formulaSCP" style="width: 100%; text-align: center;" 
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| 
{| style="text-align: center; margin:auto;" 
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|<math>\begin{array}{lll}
{I}_{\ast }={\sigma }^{2}{I}_{p}, & \quad {y}_{\ast }=\left[ \begin{matrix}y\\(d-k)\tilde{\beta }(k)\end{matrix}\right] ,& \quad {X}_{\ast }=\left[ \begin{matrix}X\\{I}_{p}\end{matrix}\right] ,\\
{Z}_{\star }=\left[ \begin{matrix}Z\\0\end{matrix}\right]  ,& \quad {\epsilon }_{\ast }=\left[ \begin{matrix}\epsilon \\{\epsilon }_{0}\end{matrix}\right], &\quad {W}_{\star }=\left[ \begin{matrix}W&0\\0&{I}_{\star }\end{matrix}\right]\end{array}</math>. 
|}
|}

Then <math display="inline">u</math> and <math display="inline">{y}_{\ast }</math> are jointly distributed as 
{| class="formulaSCP" style="width: 100%; text-align: center;" 
|-
| 
{| style="text-align: center; margin:auto;" 
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| <math>\left[ \begin{matrix}u\\{y}_{\star }\end{matrix}\right] \sim N\left[ \left[ \begin{matrix}0\\{X}_{\star }\end{matrix}\right] \right] ,{\sigma }^{2}\left[ \begin{matrix}G&G{Z}_{\star }^{'}\\{Z}_{\star }G&{H}_{\star }\end{matrix}\right]</math>
|}
|}

where <math display="inline">{H}_{\star }=Z,G{Z}_{\star }^{'}+{W}_{\star }=\left[ \begin{matrix}H&0\\0&{I}_{\star }\end{matrix}\right]</math> .The conditional distribution of <math display="inline">{y}_{\ast }</math> given <math display="inline">u</math> is <math display="inline">{y}_{\ast }\mid u\sim N\left( X,\beta +\right. </math><math>\left. {Z}_{\ast }u,{W}_{\ast }\right)</math>  and the logarithm joint density of <math display="inline">{y}_{\ast }</math> and <math display="inline">u</math> given by

{| class="formulaSCP" style="width: 100%; text-align: center;" 
|-
| <math>\begin{array}{ll}\mathrm{ln}\,f(y,u)&\, =\displaystyle\frac{-1}{2{\sigma }^{2}}\left[ {\left( {y}_{\ast }-{X}_{+}\beta -{Z}_{\ast }u\right) }^{'}{W}_{\ast }^{-1}\left( {y}_{\ast }-{X}_{+}\beta -{Z}_{+}u\right) +{u}^{'}{G}^{-1}u\right] \\
&\,\,\, -\displaystyle\frac{n+p+q}{2}\mathrm{ln}\,\left( 2\pi {\sigma }^{2}\right) -\displaystyle\frac{1}{2}\mathrm{ln}\,\left| {W}_{\ast }\right| -\displaystyle\frac{1}{2}\mathrm{ln}\,\vert G\vert \end{array}</math>
|}

The penalized log-likelihood function is obtained by succession <math display="inline">{y}_{\ast },{X}_{\ast },{Z}_{\ast }</math> and <math display="inline">{W}_{+in}</math> <math display="inline">{\left( {y}_{\ast }-{X}_{\ast }\beta -{Z}_{\ast }u\right) }^{'}{W}_{\ast }^{-1}\left( {y}_{\ast }-\right). </math><math>\left. {X}_{\ast }\beta -{Z}_{\ast }u\right) ,</math> as follows:

{| class="formulaSCP" style="width: 100%; text-align: center;" 
|-
| 
{| style="text-align: center; margin:auto;" 
|-
| <math>\begin{array}{ll}\mathrm{ln}\,f(y,u) & =\displaystyle\frac{-1}{2{\sigma }^{2}}\left[ {y}^{'}{W}^{-1}y+(d-k{)}^{2}{\tilde{\beta }}^{'}(k)\tilde{\beta }(k)-2{\beta }^{'}{X}^{'}{W}^{-1}y-2(d-k){\tilde{\beta }}^{'}(k)\beta \right. \\&\left. -2{u}^{'}{Z}^{-1}y+2{\beta }^{'}{X}^{'}{W}^{-1}Zu+{\beta }^{'}\left( X{W}^{-1}X+{I}_{p}\right) \beta +{u}^{'}{Z}^{'}{W}^{-1}Zu+{u}^{'}{G}^{-1}u\right] \\
&\, -\displaystyle\frac{n+p+q}{2}\mathrm{ln}\,\left( 2\pi {\sigma }^{2}\right) -\displaystyle\frac{1}{2}\mathrm{ln}\,\vert W\vert -\displaystyle\frac{1}{2}\mathrm{ln}\,\vert G\vert \end{array}</math>
|}
| style="width: 5px;text-align: right;white-space: nowrap;" | (3)
|}

From Eq. (3), we get the partial derivative with respect to <math display="inline">\beta</math>  and <math display="inline">\mathit{\boldsymbol{u}},</math> then set the equations to zero and by using <math display="inline">\tilde{\beta }(k,d)</math> and <math display="inline">\tilde{u}(k,d)</math> to denote the solutions give

{| class="formulaSCP" style="width: 100%; text-align: center;" 
|-
| 
{| style="text-align: center; margin:auto;" 
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|<math>\left( {\mathit{\boldsymbol{X}}}^{'}{\mathit{\boldsymbol{W}}}^{-1}\mathit{\boldsymbol{X}}+{\mathit{\boldsymbol{I}}}_{p}\right) \tilde{\mathit{\boldsymbol{\beta }}}\left( k,d\right) +{\mathit{\boldsymbol{X}}}^{'}{\mathit{\boldsymbol{W}}}^{-1}\mathit{\boldsymbol{Z}}\tilde{\mathit{\boldsymbol{u}}}\left( k,d\right) ={\mathit{\boldsymbol{X}}}^{'}{\mathit{\boldsymbol{W}}}^{-1}\mathit{\boldsymbol{y}}+\left( d-k\right) \tilde{\mathit{\boldsymbol{\beta }}}\left( k\right) </math>
|}
| style="width: 5px;text-align: right;white-space: nowrap;" | (4)
|}

{| class="formulaSCP" style="width: 100%; text-align: center;" 
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| 
{| style="text-align: center; margin:auto;" 
|-
|<math>\mathit{\boldsymbol{Z}}^{'}{\mathit{\boldsymbol{W}}}^{-1}\mathit{\boldsymbol{X}}\tilde{\mathit{\boldsymbol{\beta }}}\left( k,d\right) +\left( {\mathit{\boldsymbol{Z}}}^{'}{\mathit{\boldsymbol{W}}}^{-1}\mathit{\boldsymbol{Z}}+{\mathit{\boldsymbol{G}}}^{-1}\right) \tilde{\mathit{\boldsymbol{u}}}\left( k,d\right) ={\mathit{\boldsymbol{Z}}}^{'}{\mathit{\boldsymbol{W}}}^{-1}\mathit{\boldsymbol{y}}</math>
|}
| style="width: 5px;text-align: right;white-space: nowrap;" | (5)
|}

By solving the Eq. (5),\tilde{u}(k,d) is

{| class="formulaSCP" style="width: 100%; text-align: center;" 
|-
| 
{| style="text-align: center; margin:auto;" 
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|<math>\begin{array}{ll}\tilde{u}(k,d) & = {\left( {\mathit{\boldsymbol{Z}}}^{'}{\mathit{\boldsymbol{W}}}^{-1}\mathit{\boldsymbol{Z}}+{\mathit{\boldsymbol{G}}}^{-1}\right) }^{-1}\left( {\mathit{\boldsymbol{Z}}}^{'}{\mathit{\boldsymbol{W}}}^{-1}\mathit{\boldsymbol{y}}-{\mathit{\boldsymbol{Z}}}^{'}{\mathit{\boldsymbol{W}}}^{-1}\mathit{\boldsymbol{X}}\tilde{\mathit{\boldsymbol{\beta }}}(k,d)\right) \\
& ={\left( {\mathit{\boldsymbol{Z}}}^{'}{\mathit{\boldsymbol{W}}}^{-1}\mathit{\boldsymbol{Z}}+{\mathit{\boldsymbol{G}}}^{-1}\right) }^{-1}{\mathit{\boldsymbol{Z}}}^{'}{\mathit{\boldsymbol{W}}}^{-1}(\mathit{\boldsymbol{y}}-\mathit{\boldsymbol{X\beta }}(k,d))\end{array}</math> 
|}
| style="width: 5px;text-align: right;white-space: nowrap;" | (6)
|}

Using <math display="inline">\tilde{u}(k,d)</math> into the Eq. (4) we get

{| class="formulaSCP" style="width: 100%; text-align: center;" 
|-
| 
{| style="text-align: center; margin:auto;" 
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| <math>\begin{matrix}\left( \mathit{\boldsymbol{X}}{\mathit{\boldsymbol{W}}}^{-1}\mathit{\boldsymbol{X}}+{\mathit{\boldsymbol{I}}}_{p}\right) \tilde{\mathit{\boldsymbol{\beta }}}(k,d)+\mathit{\boldsymbol{X}}{\mathit{\boldsymbol{W}}}^{-1}\mathit{\boldsymbol{Z}}{\left( \mathit{\boldsymbol{Z}}{\mathit{\boldsymbol{W}}}^{-1}\mathit{\boldsymbol{Z}}+{\mathit{\boldsymbol{G}}}^{-1}\right) }^{-1}\mathit{\boldsymbol{Z}}{\mathit{\boldsymbol{W}}}^{-1}(\mathit{\boldsymbol{y}}-\mathit{\boldsymbol{X}}\tilde{\mathit{\boldsymbol{\beta }}}(k,d))\\=\mathit{\boldsymbol{X}}{\mathit{\boldsymbol{W}}}^{-1}\mathit{\boldsymbol{y}}+(d-k)\tilde{\mathit{\boldsymbol{\beta }}}(k)\end{matrix}</math>
|}
| style="width: 5px;text-align: right;white-space: nowrap;" | (7)
|}


Also using <math display="inline">{H}^{-1}={\left( {Z}^{'}GZ+W\right) }^{-1}={W}^{-1}-</math><math>{W}^{-1}Z{\left( {Z}^{'}{W}^{-1}Z+{G}^{-1}\right) }^{-1}{Z}^{'}{W}^{-1},</math> this equation equals to

{| class="formulaSCP" style="width: 100%; text-align: center;" 
|-
| 
{| style="text-align: center; margin:auto;" 
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| <math>\tilde{\beta }(k,d)={\left( {X}^{'}{H}^{-1}X+{I}_{p}\right) }^{-1}\left( {X}^{'}{H}^{-1}y+ (d-k)\tilde{\beta }(k)\right)</math>
|}
| style="width: 5px;text-align: right;white-space: nowrap;" | (8)
|}


In Eq. (8), if we put <math display="inline">\tilde{\mathit{\boldsymbol{\beta }}}(k)=</math><math>{\left( {\mathit{\boldsymbol{X}}}^{'}{\mathit{\boldsymbol{H}}}^{-1}\mathit{\boldsymbol{X}}+\mathit{\boldsymbol{k}}{\mathit{\boldsymbol{I}}}_{p}\right) }^{-1}{\mathit{\boldsymbol{X}}}^{'}{\mathit{\boldsymbol{H}}}^{-1}\mathit{\boldsymbol{y}},\tilde{\mathit{\boldsymbol{\beta }}}(k,d)</math> is obtained as follows 

{| class="formulaSCP" style="width: 100%; text-align: center;" 
|-
| 
{| style="text-align: center; margin:auto;" 
|-
| <math display="inline">\tilde{\beta }(k,d)=</math><math>{\left( {\mathit{\boldsymbol{X}}}^{'}{\mathit{\boldsymbol{H}}}^{-1}\mathit{\boldsymbol{X}}+{\mathit{\boldsymbol{I}}}_{p}\right) }^{-1}\left( {\mathit{\boldsymbol{X}}}^{'}{\mathit{\boldsymbol{H}}}^{-1}\mathit{\boldsymbol{X}}+\right. </math><math>\left. d{\mathit{\boldsymbol{I}}}_{p}\right) {\left( {\mathit{\boldsymbol{X}}}^{'}{\mathit{\boldsymbol{H}}}^{-1}\mathit{\boldsymbol{X}}+k{\mathit{\boldsymbol{I}}}_{p}\right) }^{-1}\mathit{\boldsymbol{X}}{\mathit{\boldsymbol{H}}}^{-1}\mathit{\boldsymbol{y}}</math>
|}
| style="width: 5px;text-align: right;white-space: nowrap;" | (9)
|}

Due to <math display="inline">\left( {Z}^{'}{W}^{-1}Z+\right. </math><math>\left. {G}^{-1}\right) G{Z}^{'}={Z}^{'}{W}^{-1}ZG{Z}^{'}+{Z}^{'}={Z}^{'}{W}^{-1}\left( ZG{Z}^{'}+\right. </math><math>\left. W\right) ={Z}^{'}{W}^{-1}H,</math> we get 

{| class="formulaSCP" style="width: 100%; text-align: center;" 
|-
| 
{| style="text-align: center; margin:auto;" 
|-
|<math display="inline">{\left( {\mathit{\boldsymbol{Z}}}^{'}{\mathit{\boldsymbol{W}}}^{-1}\mathit{\boldsymbol{Z}}+{\mathit{\boldsymbol{G}}}^{-1}\right) }^{-1}{\mathit{\boldsymbol{G}}}^{'}{\mathit{\boldsymbol{W}}}^{-1}=</math><math>\mathit{\boldsymbol{G}}{\mathit{\boldsymbol{Z}}}^{'}{\mathit{\boldsymbol{H}}}^{-1}</math> 
|}
| style="width: 5px;text-align: right;white-space: nowrap;" | (10)
|}

Using Eq. (10), <math display="inline">\tilde{u}(k,d)</math> equals to <math display="inline">\tilde{u}(k,d)=</math><math>GZ{H}^{-1}(y-X\tilde{\beta }(k,d))</math>.

In section, we obtain the stochastic restricted two parameter estimation. For this, the stochastic Linear restrictions <math display="inline">r=</math><math>R\beta +\Phi</math>  can be unified to model (1) and the restriction <math display="inline">(d-</math><math>k)\tilde{\beta },(k)=\beta +{\epsilon }_{0}</math> to give

{| class="formulaSCP" style="width: 100%; text-align: center;" 
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| 
{| style="text-align: center; margin:auto;" 
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| <math display="inline">{\mathit{\boldsymbol{y}}}_{{r}^{\star }}={\mathit{\boldsymbol{X}}}_{{r}^{\star }}\mathit{\boldsymbol{\beta }}+</math><math>{\mathit{\boldsymbol{Z}}}_{r}\mathit{\boldsymbol{u}}+{\mathit{\boldsymbol{\epsilon }}}_{\ast ,}</math>
|}
| style="width: 5px;text-align: right;white-space: nowrap;" | (11)
|}

where <math display="inline">{y}_{{r}^{\ast }}=\left[ \begin{matrix}y\\(d-k){\tilde{\beta }}_{r}(k)\\r\end{matrix}\right] ,{X}_{{r}^{\ast }}=</math><math>\left[ \begin{matrix}X\\{I}_{p}\\R\end{matrix}\right] ,{Z}_{{r}^{\ast }}=\left[ \begin{matrix}Z\\0\\0\end{matrix}\right] ,{\epsilon }_{{r}^{\ast }}=</math><math>\left[ \begin{matrix}\epsilon \\{\epsilon }_{0}\\\Phi \end{matrix}\right]</math>  and <math display="inline">{W}_{{r}^{\star }}=</math><math>\left[ \begin{matrix}W&0&0\\0&{I}_{\ast }&0\\0&0&V\end{matrix}\right] .</math> Then, the conditional distribution of <math display="inline">{y}_{\ast }</math> given <math display="inline">\mathit{\boldsymbol{u}}</math> is <math display="inline">{\mathit{\boldsymbol{y}}}_{{r}^{\ast }}\mid \mathit{\boldsymbol{u}}\sim \mathit{\boldsymbol{N}}\left( {\mathit{\boldsymbol{X}}}_{{r}^{\ast }}\mathit{\boldsymbol{\beta }}+\right. </math><math>\left. {\mathit{\boldsymbol{Z}}}_{{r}^{\ast }}\mathit{\boldsymbol{u}},{\mathit{\boldsymbol{W}}}_{{r}^{\ast }}\right)</math>  and the logarithm joint density of <math display="inline">{y}_{r}</math> and <math display="inline">u</math> given by

{| class="formulaSCP" style="width: 100%; text-align: center;" 
|-
| <math>\begin{array}{ll} \mathrm{ln}\,g(\mathit{\boldsymbol{y}},\mathit{\boldsymbol{u}}) = & \displaystyle\frac{-1}{2{\sigma }^{2}}\left[ {\left( {\mathit{\boldsymbol{y}}}_{{r}^{\ast }}-{\mathit{\boldsymbol{X}}}_{{r}^{\ast }}\mathit{\boldsymbol{\beta }}-{\mathit{\boldsymbol{Z}}}_{{r}^{\ast }}\mathit{\boldsymbol{u}}\right) }^{'}{\mathit{\boldsymbol{W}}}_{{p}^{\ast }}^{-1}\left( {\mathit{\boldsymbol{y}}}_{{r}^{\ast }}-{\mathit{\boldsymbol{X}}}_{{r}^{\ast }}\mathit{\boldsymbol{\beta }}-{\mathit{\boldsymbol{Z}}}_{{r}^{\ast }}\mathit{\boldsymbol{u}}\right) +{\mathit{\boldsymbol{u}}}^{'}{\mathit{\boldsymbol{G}}}^{-1}\mathit{\boldsymbol{u}}\right] \\
& -\displaystyle\frac{n+m+p+q}{2}\mathrm{ln}\,\left( 2\pi {\sigma }^{2}\right) -\displaystyle\frac{1}{2}\mathrm{ln}\,\left| {\mathit{\boldsymbol{W}}}_{r\ast }\right| -\displaystyle\frac{1}{2}\mathrm{ln}\,\vert \mathit{\boldsymbol{G}}\vert \end{array}</math>
|}


Substituting <math display="inline">{y}_{r},{X}_{{r}^{\ast }}{Z}_{{r}^{\ast }}</math> and <math display="inline">{W}_{{r}^{+}}</math> to <math display="inline">{\left( {y}_{{r}^{\ast }}-{X}_{{r}^{\ast }}\beta -{Z}_{{r}^{\ast }}u\right) }^{'}{W}_{{\gamma }^{\ast }}^{-1}\left( {y}_{{r}^{\ast }}-\right. </math><math>\left. {X}_{{r}^{\ast }}\beta -{Z}_{{r}^{\ast }}u\right) ,</math> the penalized log-likelihood function is obtained as follows:

{| class="formulaSCP" style="width: 100%; text-align: center;" 
|-
| 
{| style="text-align: center; margin:auto;" 
|-
|  <math>\begin{matrix}\mathrm{ln}\,g(y,u)=\displaystyle\frac{-1}{2{\sigma }^{2}}\left[ {y}^{'}{W}^{-1}y+(d-k{)}^{2}{\tilde{\beta }}_{r}^{'}(k){\tilde{\beta }}_{r}(k)+{r}^{'}{V}^{-1}r-2{\beta }^{'}X{W}^{-1}y-2(d-k){\tilde{\beta }}_{r}^{'}(k)\beta \right. \\-2{u}^{'}{Z}^{'}{W}^{-1}y-2{\beta }^{'}{R}^{'}{V}^{-1}r+\beta {R}^{'}{V}^{-1}R\beta +\beta \left( X{W}^{-1}X+{I}_{p}\right) \beta +2{u}^{'}Z{W}^{-1}X\beta \\\left. +{u}^{'}Z{W}^{-1}Zu+{u}^{'}{G}^{-1}u\right] -\displaystyle\frac{n+m+p+q}{2}\mathrm{ln}\,\left( 2\pi {\sigma }^{2}\right) -\displaystyle\frac{1}{2}\mathrm{ln}\,{W}_{{r}^{\star }}\left| -\displaystyle\frac{1}{2}ln\right| G\mid \end{matrix}</math>
|}
| style="width: 5px;text-align: right;white-space: nowrap;" | (12)
|}


From Eq. (12), we get the partial derivative with respect to <math display="inline">\beta</math>  and <math display="inline">\mathit{\boldsymbol{u}},</math> then set the equations to zero and by using <math display="inline">{\tilde{\beta }}_{r}(k,d)</math> and <math display="inline">{\tilde{u}}_{r}(k,d)</math> to denote the solutions give

{| class="formulaSCP" style="width: 100%; text-align: center;" 
|-
| 
{| style="text-align: center; margin:auto;" 
|-
| <math>\left( {\mathit{\boldsymbol{X}}}^{'}{\mathit{\boldsymbol{W}}}^{-1}\mathit{\boldsymbol{X}}+{\mathit{\boldsymbol{R}}}^{'}{\mathit{\boldsymbol{V}}}^{-1}\mathit{\boldsymbol{R}}+{\mathit{\boldsymbol{I}}}_{p}\right) {\tilde{\mathit{\boldsymbol{\beta }}}}_{r}(k,d)+\mathit{\boldsymbol{X}}{\mathit{\boldsymbol{W}}}^{-1}\mathit{\boldsymbol{Z}}{\tilde{\mathit{\boldsymbol{u}}}}_{r}(k,d)=\mathit{\boldsymbol{X}}{\mathit{\boldsymbol{W}}}^{-1}\mathit{\boldsymbol{y}}+(d-k)\tilde{\mathit{\boldsymbol{\beta }}},(k)+{\mathit{\boldsymbol{R}}}^{'}{\mathit{\boldsymbol{V}}}^{-1}\mathit{\boldsymbol{r}} </math>
|}
| style="width: 5px;text-align: right;white-space: nowrap;" | (13)
|}

{| class="formulaSCP" style="width: 100%; text-align: center;" 
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| 
{| style="text-align: center; margin:auto;" 
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| <math>{\mathit{\boldsymbol{Z}}}^{'}{\mathit{\boldsymbol{W}}}^{-1}\mathit{\boldsymbol{X}}{\tilde{\mathit{\boldsymbol{\beta }}}}_{r}\left( k,d\right) +\left( \mathit{\boldsymbol{Z}}{\mathit{\boldsymbol{W}}}^{-1}\mathit{\boldsymbol{Z}}+{\mathit{\boldsymbol{G}}}^{-1}\right) {\tilde{\mathit{\boldsymbol{u}}}}_{r}\left( k,d\right) =\mathit{\boldsymbol{Z}}{\mathit{\boldsymbol{W}}}^{-1}\mathit{\boldsymbol{y}}</math>
|}
| style="width: 5px;text-align: right;white-space: nowrap;" | (14)
|}


By solving these equations similar to Eqs. (4) and (5), the following results are obtained

{| class="formulaSCP" style="width: 100%; text-align: center;" 
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| 
{| style="text-align: center; margin:auto;" 
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|  <math>\begin{array}{ll}{\tilde{\mathit{\boldsymbol{\beta }}}}_{r}\left( k,d\right) & ={\left( \mathit{\boldsymbol{X}}{\mathit{\boldsymbol{H}}}^{-1}\mathit{\boldsymbol{X}}+{\mathit{\boldsymbol{R}}}^{'}{\mathit{\boldsymbol{V}}}^{-1}\mathit{\boldsymbol{R}}+{\mathit{\boldsymbol{I}}}_{p}\right) }^{-1}\left( \mathit{\boldsymbol{X}}{\mathit{\boldsymbol{H}}}^{-1}\mathit{\boldsymbol{X}}+{\mathit{\boldsymbol{R}}}^{'}{\mathit{\boldsymbol{V}}}^{-1}\mathit{\boldsymbol{R}}+d{\mathit{\boldsymbol{I}}}_{p}\right) \\
& \times {\left( \mathit{\boldsymbol{X}}{\mathit{\boldsymbol{H}}}^{-1}\mathit{\boldsymbol{X}}+{\mathit{\boldsymbol{R}}}^{'}{\mathit{\boldsymbol{V}}}^{-1}\mathit{\boldsymbol{R}}+k{\mathit{\boldsymbol{I}}}_{p}\right) }^{-1}\left( \mathit{\boldsymbol{X}}{\mathit{\boldsymbol{H}}}^{-1}\mathit{\boldsymbol{y}}+{\mathit{\boldsymbol{R}}}^{\boldsymbol{'}}{\mathit{\boldsymbol{V}}}^{-1}\mathit{\boldsymbol{r}}\right)\end{array}</math> 
|}
| style="width: 5px;text-align: right;white-space: nowrap;" | (15)
|}

{| class="formulaSCP" style="width: 100%; text-align: center;" 
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{| style="text-align: center; margin:auto;" 
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|  <math>{\tilde{\mathit{\boldsymbol{u}}}}_{r}\left( k,d\right) =\mathit{\boldsymbol{G}}{\mathit{\boldsymbol{Z}}}^{'}{\mathit{\boldsymbol{H}}}^{-1}\left( \mathit{\boldsymbol{y}}-\mathit{\boldsymbol{X}}{\tilde{\mathit{\boldsymbol{\beta }}}}_{r}\left( k,d\right) \right)  </math>
|}
| style="width: 5px;text-align: right;white-space: nowrap;" | (16)
|}

==3. Estimation of variance parameters==

In linear mixed models, the variance parameter within <math display="inline">G</math> and <math display="inline">W</math> are often unknown that several methods have been proposed by Searle <math display="inline">[16,20-</math><math>22]</math> to estimate them. In this section, we estimate the variance parameters using the ML method. The marginal distribution of <math display="inline">{y}_{\ast }</math> is <math display="inline">N\left( \mathit{\boldsymbol{X}}\cdot \mathit{\boldsymbol{\beta }},{\sigma }^{2}{\mathit{\boldsymbol{H}}}_{\ast }\right) ,</math> therefore we can write the marginal log-likelihood function of <math display="inline">\mathit{\boldsymbol{y}}</math>

{| class="formulaSCP" style="width: 100%; text-align: left;" 
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| 
{| style="text-align: center; margin:auto;width: 100%;" 
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| style="text-align: center;" | <math>{l}_{ML}\left( \mathit{\boldsymbol{\beta }},\mathit{\boldsymbol{\phi }},{\mathit{\boldsymbol{y}}}_{\ast }\right) =</math><math>\frac{-1}{2{\sigma }^{2}}\left\{ {\left( {\mathit{\boldsymbol{y}}}_{\ast }-{\mathit{\boldsymbol{X}}}_{\ast }\mathit{\boldsymbol{\beta }}\right) }^{'}{\mathit{\boldsymbol{H}}}_{\ast }^{-1}\left( {\mathit{\boldsymbol{y}}}_{\ast }-\right. \right. </math><math>\left. \left. {\mathit{\boldsymbol{X}}}_{\ast }\mathit{\boldsymbol{\beta }}\right) \right\} -</math><math>\frac{n+p}{2}\mathrm{ln}\,\left( 2\pi {\mathit{\boldsymbol{\sigma }}}^{2}\right) -</math><math>\frac{1}{2}\mathrm{ln}\,\left| {\mathit{\boldsymbol{H}}}_{\ast }\right| </math>
|}
| style="width: 5px;text-align: right;white-space: nowrap;" |(17)
|}

where <math display="inline">\phi ={\left( {\mathit{\boldsymbol{K}}}^{'},{\sigma }^{2}\right) }^{'},\mathit{\boldsymbol{k}}=</math><math>{\left( {\zeta }^{'},{\xi }^{'}\right) }^{'}</math> and are <math display="inline">\left( {r}_{1}+\right. </math><math>\left. {r}_{2}+1\right) \times 1</math> and <math display="inline">\left( {r}_{1}+\right. </math><math>\left. {r}_{2}\right) \times 1</math> vectors of unknown parameters, respectively. Differentiating the Eq. (17) with respect to <math display="inline">\beta ,{\sigma }^{2}</math> and <math display="inline">{\kappa }_{j}=</math><math>1,\ldots ,{r}_{1}+{r}_{2}</math> the partial derivatives is obtained as

{| class="formulaSCP" style="width: 100%; text-align: left;" 
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| 
{| style="text-align: center; margin:auto;width: 100%;" 
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| style="text-align: center;" | <math>\frac{\partial {l}_{ML}\left( \mathit{\boldsymbol{\beta }},\mathit{\boldsymbol{\phi }};{\mathit{\boldsymbol{y}}}_{\ast }\right) }{\partial \mathit{\boldsymbol{\beta }}}=</math><math>\frac{-1}{{\sigma }^{2}}\left( {\mathit{\boldsymbol{X}}}_{\ast }^{'}{\mathit{\boldsymbol{H}}}_{\ast }^{-1}{\mathit{\boldsymbol{X}}}_{\ast }\mathit{\boldsymbol{\beta }}-\right. </math><math>\left. {\mathit{\boldsymbol{X}}}_{\ast }^{'}{\mathit{\boldsymbol{H}}}_{\ast }^{-1}{\mathit{\boldsymbol{y}}}_{\ast }\right) ,</math>  
|}
| style="width: 5px;text-align: right;white-space: nowrap;" |(18)
|}

{| class="formulaSCP" style="width: 100%; text-align: left;" 
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| 
{| style="text-align: center; margin:auto;width: 100%;" 
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| style="text-align: center;" |<math>\frac{\partial {l}_{ML}\left( \mathit{\boldsymbol{\beta }},\mathit{\boldsymbol{\phi }};{\mathit{\boldsymbol{y}}}_{\ast }\right) }{\partial {\sigma }^{2}}=</math><math>\frac{-(n+p)}{2{\sigma }^{2}}+\frac{{\left( {\mathit{\boldsymbol{y}}}_{\ast }-\mathit{\boldsymbol{X}}\cdot \mathit{\boldsymbol{\beta }}\right) }^{'}{\mathit{\boldsymbol{H}}}_{\cdot }^{-1}\left( {\mathit{\boldsymbol{y}}}_{\ast }-\mathit{\boldsymbol{X}}\cdot \mathit{\boldsymbol{\beta }}\right) }{2{\sigma }^{4}},</math> 
|}
| style="width: 5px;text-align: right;white-space: nowrap;" |(19)
|}

{| class="formulaSCP" style="width: 100%; text-align: left;" 
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| 
{| style="text-align: center; margin:auto;width: 100%;" 
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| style="text-align: center;" |<math>\frac{\partial {l}_{ML}\left( \mathit{\boldsymbol{\beta }},\mathit{\boldsymbol{\phi }};{\mathit{\boldsymbol{y}}}_{\ast }\right) }{\partial {\kappa }_{i}}=</math><math>\frac{-1}{2}\mathrm{tr}\,\left( {\mathit{\boldsymbol{H}}}_{\ast }^{-1}{\dot{\mathit{\boldsymbol{H}}}}_{{\ast }_{j}}\right) +</math><math>\frac{{\left( {\mathit{\boldsymbol{y}}}_{\ast }-{\mathit{\boldsymbol{X}}}_{\ast }\mathit{\boldsymbol{\beta }}\right) }^{'}{\mathit{\boldsymbol{H}}}_{\ast }^{-1}{\dot{\mathit{\boldsymbol{H}}}}_{\ast }{\mathit{\boldsymbol{H}}}_{\ast }^{-1}\left( {\mathit{\boldsymbol{y}}}_{\ast }-\mathit{\boldsymbol{X}}\cdot \mathit{\boldsymbol{\beta }}\right) }{2{\sigma }^{2}} </math>
|}
| style="width: 5px;text-align: right;white-space: nowrap;" |(20)
|}

where <math display="inline">{\dot{H}}_{\ast j}=\partial {H}_{\ast }/\partial {\kappa }_{j}</math>. Setting Eqs. (18)-(20) equal to zero and using <math display="inline">\tilde{\beta }(k,d),{\tilde{\sigma }}^{2}(k,d)</math> and <math display="inline">\tilde{H}</math> and instead of <math display="inline">\mathit{\boldsymbol{\beta }},{\sigma }^{2}</math> and <math display="inline">\mathit{\boldsymbol{H}}</math> gives

{| class="formulaSCP" style="width: 100%; text-align: left;" 
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| 
{| style="text-align: center; margin:auto;width: 100%;" 
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| style="text-align: center;" |<math>\&X{\tilde{H}}_{\ast }^{-1}X,\tilde{\beta }(k,d)={X}^{'}{\tilde{H}}_{\ast }^{-1}{y}_{\star }</math> 
|}
| style="width: 5px;text-align: right;white-space: nowrap;" |(21)
|}

{| class="formulaSCP" style="width: 100%; text-align: left;" 
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| 
{| style="text-align: center; margin:auto;width: 100%;" 
|-
| style="text-align: center;" |<math>(n+p){\tilde{\sigma }}^{2}(k,d)={\left( {y}_{\star }-{X}_{\ast }\tilde{\beta }\left( k,d\right) \right) }^{'}{\tilde{H}}_{\ast }^{-1}\left( {y}_{\star }-{X}_{\star }\tilde{\beta }\left( k,d\right) \right)</math>  
|}
| style="width: 5px;text-align: right;white-space: nowrap;" |(22)
|}

{| class="formulaSCP" style="width: 100%; text-align: left;" 
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| 
{| style="text-align: center; margin:auto;width: 100%;" 
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| style="text-align: center;" |<math>(\mathrm{tr}\,\left( {\tilde{H}}_{\ast }^{-1}{\tilde{H}}_{\ast j}\right) =\frac{{\left( {y}_{\star }-{X}_{\ast }\tilde{\beta }\left( k,d\right) \right) }^{'}{\tilde{H}}_{\ast }^{-1}{\tilde{H}}_{\ast j}{\tilde{H}}_{\ast }^{-1}\left( {y}_{\star }-{X}_{\star }\tilde{\beta }\left( k,d\right) \right) }{{\tilde{\sigma }}^{2}\left( k,d\right) }</math>
|}
| style="width: 5px;text-align: right;white-space: nowrap;" |(23)
|}

Solving Eqs. (21) and (23) yields the estimators

{| class="formulaSCP" style="width: 100%; text-align: left;" 
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| 
{| style="text-align: center; margin:auto;width: 100%;" 
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| style="text-align: center;" |<math>\begin{array}{ll}\tilde{\mathit{\boldsymbol{\beta }}}(k,d)&={\left( {\mathit{\boldsymbol{X}}}_{\ast }^{'}{\tilde{\mathit{\boldsymbol{H}}}}_{\ast }^{-1}{\mathit{\boldsymbol{X}}}_{\ast }\right) }^{-1}{\mathit{\boldsymbol{X}}}_{\ast }^{'}{\tilde{\mathit{\boldsymbol{H}}}}_{\ast }^{-1}{\mathit{\boldsymbol{y}}}_{\ast }\\
&={\left( {\mathit{\boldsymbol{X}}}^{'}{\tilde{\mathit{\boldsymbol{H}}}}^{-1}\mathit{\boldsymbol{X}}+{\mathit{\boldsymbol{I}}}_{p}\right) }^{-1}\left( {\mathit{\boldsymbol{X}}}^{'}{\tilde{\mathit{\boldsymbol{H}}}}^{-1}\mathit{\boldsymbol{X}}+d{\mathit{\boldsymbol{I}}}_{p}\right) {\left( {\mathit{\boldsymbol{X}}}^{'}{\tilde{\mathit{\boldsymbol{H}}}}^{-1}\mathit{\boldsymbol{X}}+\mathit{\boldsymbol{k}}{\mathit{\boldsymbol{I}}}_{p}\right) }^{-1}{\mathit{\boldsymbol{X}}}^{'}{\tilde{\mathit{\boldsymbol{H}}}}^{-1}\mathit{\boldsymbol{y}}\end{array}</math>
|}
| style="width: 5px;text-align: right;white-space: nowrap;" |(24)
|}

{| class="formulaSCP" style="width: 100%; text-align: left;" 
|-
| 
{| style="text-align: center; margin:auto;width: 100%;" 
|-
| style="text-align: center;" |<math>\begin{array}{ll}{\tilde{\sigma }}^{2}(k,d)&=\displaystyle\frac{1}{(n+p)}{\left( {\mathit{\boldsymbol{y}}}_{\ast }-{\mathit{\boldsymbol{X}}}_{\ast }\tilde{\mathit{\boldsymbol{\beta }}}(k,d)\right) }^{'}{\tilde{\mathit{\boldsymbol{H}}}}_{\cdot }^{-1}\left( {\mathit{\boldsymbol{y}}}_{\ast }-{\mathit{\boldsymbol{X}}}_{\ast }\tilde{\mathit{\boldsymbol{\beta }}}(k,d)\right) \\
& =\displaystyle\frac{1}{(n+p)}\left\{ (\mathit{\boldsymbol{y}}-\mathit{\boldsymbol{X}}\tilde{\mathit{\boldsymbol{\beta }}}(k,d){)}^{'}{\tilde{\mathit{\boldsymbol{H}}}}^{-1}(\mathit{\boldsymbol{y}}-\mathit{\boldsymbol{X}}\tilde{\mathit{\boldsymbol{\beta }}}(k,d))\right. \\
  & \,\,+ \left. (\tilde{\mathit{\boldsymbol{\beta }}}(k,d)-(d-k)\tilde{\mathit{\boldsymbol{\beta }}}(k){)}^{'}(\tilde{\mathit{\boldsymbol{\beta }}}(k,d)-(d-k)\tilde{\mathit{\boldsymbol{\beta }}}(k))\right\} \end{array}</math>
|}
| style="width: 5px;text-align: right;white-space: nowrap;" |(25)
|}


Eq. (23) depends on <math display="inline">\tilde{\mathit{\boldsymbol{\beta }}}(k,d)</math> and <math display="inline">{\tilde{\sigma }}^{2}(k,d),</math> so iterative procedures must be used to solve <math display="inline">{K}_{j}</math>'s. In the statistical literature, there are four iterative procedures to estimates variance parameters, which include: "Newton-Raphson (NR), Expectation Maximization algorithm (EM), Fisher Scoring (FS) and the Average Information (AI) algorithms". See [22] for details of these procedures. Note that in the stochastic restricted two parameter methods, the ML estimators is obtained similar Eqs. (21),(22) and (23).

==4. Comparison of estimators==

In this section, we compare the estimator <math display="inline">\tilde{\mathit{\boldsymbol{\beta }}}(k,d)</math> with <math display="inline">\tilde{\mathit{\boldsymbol{\beta }}}</math> and the estimator <math display="inline">{\tilde{\mathit{\boldsymbol{\beta }}}}_{r}(k,d)</math> with <math display="inline">{\tilde{\mathit{\boldsymbol{\beta }}}}_{r}</math> using the mean squares error matrix (MSEM) sense. The estimator <math display="inline">{\tilde{\mathit{\boldsymbol{\beta }}}}_{2}</math> is superior to <math display="inline">{\tilde{\mathit{\boldsymbol{\beta }}}}_{1}</math> with respect to the MSEM sense, if and only if <math display="inline">\Delta \left( {\tilde{\beta }}_{1},{\tilde{\beta }}_{2}\right) =</math><math>MSEM\left( {\tilde{\beta }}_{1}\right) -MSEM\left( {\tilde{\beta }}_{2}\right) >0,</math> that is, <math display="inline">\Delta \left( {\tilde{\beta }}_{1},{\tilde{\beta }}_{2}\right)</math>  is a positive definite (pd) matrix. The mean-square error matrix for the estimator <math display="inline">\tilde{\mathit{\boldsymbol{\beta }}}(k,d)</math> is given as

{| class="formulaSCP" style="width: 100%; text-align: left;" 
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| 
{| style="text-align: center; margin:auto;width: 100%;" 
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| style="text-align: center;" | <math>\mathrm{MSEM}\,(\tilde{\mathit{\boldsymbol{\beta }}}(k,d),\mathit{\boldsymbol{\beta }})=\mathrm{Var}\,(\tilde{\mathit{\boldsymbol{\beta }}}(k,d))+\mathrm{bias}\,(\tilde{\mathit{\boldsymbol{\beta }}}(k,d))\mathrm{bias}\,(\tilde{\mathit{\boldsymbol{\beta }}}(k,d){)}^{'}</math>
|}
|}

The variance matrix of <math display="inline">\tilde{\beta }(k,d)</math> is
{| class="formulaSCP" style="width: 100%; text-align: center;" 
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| <math>V~ar~(\tilde{\beta }(k,d))={\sigma }^{2}{T}_{1}{X}^{'}{H}^{-1}X{T}_{1}^{'}</math>
|}

where <math display="inline">{T}_{1}={\left( {X}^{'}{H}^{-1}X+{I}_{p}\right) }^{-1}\left( {X}^{'}{H}^{-1}X+\right. </math><math>\left. d{I}_{p}\right) {\left( {X}^{'}{H}^{-1}X+k{I}_{p}\right) }^{-1}.</math> The bias <math display="inline">(\tilde{\beta }(k,d))</math> is given as
{| class="formulaSCP" style="width: 100%; text-align: center;" 
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| bias <math>(\tilde{\beta }(k,d))=E(\tilde{\beta }(k,d)-\beta )=-{\left( \mathit{\boldsymbol{X}}{\mathit{\boldsymbol{H}}}^{-1}\mathit{\boldsymbol{X}}+{\mathit{\boldsymbol{I}}}_{p}\right) }^{-1}{\left( \mathit{\boldsymbol{X}}{\mathit{\boldsymbol{H}}}^{-1}\mathit{\boldsymbol{X}}+k{\mathit{\boldsymbol{I}}}_{p}\right) }^{-1}\left( (k+1-\right. </math><math>\left. d)\mathit{\boldsymbol{X}}{\mathit{\boldsymbol{H}}}^{-1}\mathit{\boldsymbol{X}}+\right. </math><math>\left. k{\mathit{\boldsymbol{I}}}_{p}\right) \mathit{\boldsymbol{\beta }}</math>
|}

The mean-square error matrix for the estimator <math display="inline">{\tilde{\beta }}_{r}(k,d)</math> is given as

{| class="formulaSCP" style="width: 100%; text-align: center;" 
|-
| <math>\mathrm{MSEM}\,\left( {\tilde{\mathit{\boldsymbol{\beta }}}}_{r}(k,d),\mathit{\boldsymbol{\beta }}\right) =</math><math>{\sigma }^{2}{\mathit{\boldsymbol{T}}}_{2}\left( {\mathit{\boldsymbol{X}}}^{'}{\mathit{\boldsymbol{H}}}^{-1}\mathit{\boldsymbol{X}}+\right. </math><math>\left. {\mathit{\boldsymbol{R}}}^{'}{\mathit{\boldsymbol{V}}}^{-1}\mathit{\boldsymbol{R}}\right) {\mathit{\boldsymbol{T}}}_{2}^{'}+\mathrm{bias}\,\left( {\mathit{\boldsymbol{\beta }}}_{r}(k,d)\right) \mathrm{bias}\,{\left( {\mathit{\boldsymbol{\beta }}}_{r}(k,d)\right) }^{'}</math>
|}

where 

{| class="formulaSCP" style="width: 100%; text-align: center;" 
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| <math>{\mathit{\boldsymbol{T}}}_{2}={\left( {\mathit{\boldsymbol{X}}}^{'}{\mathit{\boldsymbol{H}}}^{-1}\mathit{\boldsymbol{X}}+{\mathit{\boldsymbol{R}}}^{'}{\mathit{\boldsymbol{V}}}^{-1}\mathit{\boldsymbol{R}}+{\mathit{\boldsymbol{I}}}_{p}\right) }^{-1}\left( {\mathit{\boldsymbol{X}}}^{'}{\mathit{\boldsymbol{H}}}^{-1}\mathit{\boldsymbol{X}}+\right. </math><math>\left. {\mathit{\boldsymbol{R}}}^{'}{\mathit{\boldsymbol{V}}}^{-1}\mathit{\boldsymbol{R}}+\right. </math><math>\left. d{\mathit{\boldsymbol{I}}}_{p}\right) {\left( \mathit{\boldsymbol{X}}{\mathit{\boldsymbol{H}}}^{-1}\mathit{\boldsymbol{X}}+{\mathit{\boldsymbol{R}}}^{\boldsymbol{'}}{\mathit{\boldsymbol{V}}}^{-1}\mathit{\boldsymbol{R}}+\mathit{\boldsymbol{k}}{\mathit{\boldsymbol{I}}}_{p}\right) }^{-1}</math>
|}
and 

{| class="formulaSCP" style="width: 100%; text-align: center;" 
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| <math>\begin{array}{ll}{\rm  bias}\,\left( {\tilde{\mathit{\boldsymbol{\beta }}}}_{r}(k,d)\right) & =-{\left( \mathit{\boldsymbol{X}}{\mathit{\boldsymbol{H}}}^{-1}\mathit{\boldsymbol{X}}+{\mathit{\boldsymbol{R}}}^{'}{\mathit{\boldsymbol{V}}}^{-1}\mathit{\boldsymbol{R}}+{\mathit{\boldsymbol{I}}}_{p}\right) }^{-1}{\left( \mathit{\boldsymbol{X}}{\mathit{\boldsymbol{H}}}^{-1}\mathit{\boldsymbol{X}}+{\mathit{\boldsymbol{R}}}^{'}{\mathit{\boldsymbol{V}}}^{-1}\mathit{\boldsymbol{R}}+k{\mathit{\boldsymbol{I}}}_{p}\right) }^{-1}\\
& \times \left( (k+1-d)\left( \mathit{\boldsymbol{X}}{\mathit{\boldsymbol{H}}}^{-1}\mathit{\boldsymbol{X}}+ {\mathit{\boldsymbol{R}}}^{'}{\mathit{\boldsymbol{V}}}^{-1}\mathit{\boldsymbol{R}}\right) + k{\mathit{\boldsymbol{I}}}_{p}\right) \mathit{\boldsymbol{\beta }}\end{array}</math>
|}


===4.1. Comparison the Estimator  <math display="inline">\tilde{\mathit{\boldsymbol{\beta }}}\boldsymbol{(}\mathit{\boldsymbol{k}}\boldsymbol{,}\mathit{\boldsymbol{d}}\boldsymbol{)}</math>''' with ''' <math display="inline">\tilde{\mathit{\boldsymbol{\beta }}}</math>===

The <math display="inline">MSEM</math> of <math display="inline">\tilde{\mathit{\boldsymbol{\beta }}}</math> is <math display="inline">\mathrm{MSEM}\,(\tilde{\mathit{\boldsymbol{\beta }}})=</math><math>{\sigma }^{2}{\mathit{\boldsymbol{A}}}^{-1},</math> where <math display="inline">{\mathit{\boldsymbol{A}}}_{1}=</math><math>\left( \mathit{\boldsymbol{X}}{\mathit{\boldsymbol{H}}}^{-1}\mathit{\boldsymbol{X}}\right) ,</math> and the <math display="inline">MSEM</math> of <math display="inline">\tilde{\mathit{\boldsymbol{\beta }}}(k,d)</math> is

{| class="formulaSCP" style="width: 100%; text-align: center;" 
|-
| <math>\mathrm{MSEM}\,(\tilde{\mathit{\boldsymbol{\beta }}}(k,d))={\sigma }^{2}{\mathit{\boldsymbol{T}}}_{1}{\mathit{\boldsymbol{A}}}_{1}{\mathit{\boldsymbol{T}}}_{1}^{'}+</math><math>\left( {\mathit{\boldsymbol{T}}}_{1}{\mathit{\boldsymbol{A}}}_{1}-{\mathit{\boldsymbol{I}}}_{p}\right) \beta {\mathit{\boldsymbol{\beta }}}^{'}{\left( {\mathit{\boldsymbol{T}}}_{1}{\mathit{\boldsymbol{A}}}_{1}-{\mathit{\boldsymbol{I}}}_{p}\right) }^{'}</math>
|}


The estimator <math display="inline">\tilde{\beta }(k,d)</math> is superior to the estimator <math display="inline">\tilde{\beta }</math> under the MSEM sense, if and only if <math display="inline">\mathrm{MSEM}\,(\tilde{\mathit{\boldsymbol{\beta }}})-\mathrm{MSEM}\,(\tilde{\mathit{\boldsymbol{\beta }}}(k,d))>0</math> then

{| class="formulaSCP" style="width: 100%; text-align: center;" 
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| <math>{\Delta }_{1}=MSEM(\tilde{\beta })-MSEM(\tilde{\beta }(k,d))={\sigma }^{2}\left( {A}_{1}^{-1}-\right. </math><math>\left. {T}_{1}{A}_{1}{T}_{1}\right) -\left( {T}_{1}{A}_{1}-{I}_{p}\right) \beta \beta {\left( {T}_{1}{A}_{1}-{I}_{p}\right) }^{'}>0</math>
|}


According to Farebrother <math display="inline">(1976),</math> if <math display="inline">{\sigma }^{2}\left( {A}_{1}^{-1}-\right. </math><math>\left. {T}_{1}{A}_{1}{T}_{1}\right) >0,</math> then the necessary and sufficient condition for <math display="inline">\tilde{\mathit{\boldsymbol{\beta }}}(k,d)</math> to be superior to <math display="inline">\tilde{\mathit{\boldsymbol{\beta }}}</math> is <math display="inline">{\mathit{\boldsymbol{\beta }}}^{'}{\left( {\mathit{\boldsymbol{T}}}_{1}{\mathit{\boldsymbol{A}}}_{1}-{\mathit{\boldsymbol{I}}}_{p}\right) }^{'}{\left[ {\sigma }^{2}\left( {\mathit{\boldsymbol{A}}}_{1}^{-1}-{\mathit{\boldsymbol{T}}}_{1}{\mathit{\boldsymbol{A}}}_{1}{\mathit{\boldsymbol{T}}}_{1}\right) \right] }^{-1}\left( {\mathit{\boldsymbol{T}}}_{1}{\mathit{\boldsymbol{A}}}_{1}-\right. </math><math>\left. {\mathit{\boldsymbol{I}}}_{p}\right) \mathit{\boldsymbol{\beta }}<1</math>.

==5. Selection of parameters  <math display="inline">\mathit{\boldsymbol{k}}</math> and  <math display="inline">\mathit{\boldsymbol{d}}</math>==

In the linear regression model, choosing the parameter <math display="inline">k</math> is important so many statisticians were suggested several methods for obtaining this parameter. These methods were proposed by many researchers [23-29] and others. According to Ozkale and Can [18], "we rewrite model (1) in the form of a marginal model in which random effects are not explicitly defined:

{| class="formulaSCP" style="width: 100%; text-align: center;" 
|-
| 
{| style="text-align: center; margin:auto;" 
|-
| <math display="inline">\mathit{\boldsymbol{y}}=\mathit{\boldsymbol{X\beta }}+\mathit{\boldsymbol{S}},{\, }\mathit{\boldsymbol{S}}=</math><math>\mathit{\boldsymbol{Zu}}+\mathit{\boldsymbol{\epsilon }}\sim N(0,\mathit{\boldsymbol{H}})</math>
|}
| style="width: 5px;text-align: right;white-space: nowrap;" | (26)
|}


Because <math display="inline">\mathit{\boldsymbol{H}}</math> is pd, then there is a nonsingular symmetric matrix <math display="inline">\mathit{\boldsymbol{N}}</math> such that <math display="inline">\mathit{\boldsymbol{H}}=</math><math>{\mathit{\boldsymbol{N}}}^{'}\mathit{\boldsymbol{N}}</math>. If we multiply both sides of model (42) by <math display="inline">{\boldsymbol{N}}^{-1}</math>, we get <math display="inline">{\mathit{\boldsymbol{y}}}^{\ast }=</math><math>{\mathit{\boldsymbol{X}}}^{\ast }\mathit{\boldsymbol{\beta }}+{\mathit{\boldsymbol{S}}}^{\ast }</math>, where <math display="inline">\dot{\mathit{\boldsymbol{y}}}={\mathit{\boldsymbol{N}}}^{-1}\mathit{\boldsymbol{y}},{\mathit{\boldsymbol{X}}}^{\ast }=</math><math>{\mathit{\boldsymbol{N}}}^{-1}\mathit{\boldsymbol{X}}</math>, 
<math display="inline">{\mathit{\boldsymbol{S}}}^{\ast }={\mathit{\boldsymbol{N}}}^{-1}\mathit{\boldsymbol{S}}</math> and <math display="inline">\mathrm{Var}\,\left( {\mathit{\boldsymbol{S}}}^{\ast }\right) ={\mathit{\boldsymbol{I}}}_{n}</math>. The matrix <math display="inline">{\mathit{\boldsymbol{X}}}^{\ast }{\mathit{\boldsymbol{X}}}^{\ast }=</math><math>{\mathit{\boldsymbol{X}}}^{'}{\mathit{\boldsymbol{H}}}^{-1}\mathit{\boldsymbol{X}}</math> is symmetric, so there is an orthogonal matrix <math display="inline">\mathit{\boldsymbol{P}}</math> such that <math display="inline">{\mathit{\boldsymbol{P}}}^{'}\mathit{\boldsymbol{P}}=</math><math>\mathit{\boldsymbol{P}}{\mathit{\boldsymbol{P}}}^{'}={\mathit{\boldsymbol{I}}}_{p}</math> and <math display="inline">{\mathit{\boldsymbol{P}}}^{'}{\mathit{\boldsymbol{X}}}^{\ast }{\mathit{\boldsymbol{X}}}^{\ast }\mathit{\boldsymbol{P}}=</math><math>\boldsymbol{\Lambda }=\mathrm{diag}\,\left( {\lambda }_{1},\ldots ,{\lambda }_{p}\right) ,</math> where
<math display="inline">{\lambda }_{1}\geq {\lambda }_{2}\geq \ldots \geq {\lambda }_{p}</math> are the ordered eigenvalues of <math display="inline">{\mathit{\boldsymbol{X}}}^{\ast }{\mathit{\boldsymbol{X}}}^{\ast }</math>. Then model (26) can be rewritten in a canonical form as <math display="inline">{\mathit{\boldsymbol{y}}}^{\ast }=</math><math>{\mathit{\boldsymbol{X}}}^{\ast \ast }\mathit{\boldsymbol{\gamma }}+{\mathit{\boldsymbol{S}}}^{\ast }</math>, where <math display="inline">{\mathit{\boldsymbol{X}}}^{\ast \ast }=</math><math>{\mathit{\boldsymbol{X}}}^{\ast }\mathit{\boldsymbol{P}}</math> and <math display="inline">\mathit{\boldsymbol{\gamma }}=</math><math>{\mathit{\boldsymbol{P}}}^{'}\mathit{\boldsymbol{\beta }}''</math>. Under this model, we get the following representation:

{| class="formulaSCP" style="width: 100%; text-align: center;" 
|-
| <math>\tilde{\gamma }(k,d)={\left( \boldsymbol{\Lambda }+{\mathit{\boldsymbol{I}}}_{p}\right) }^{-1}\left( \boldsymbol{\Lambda }+\right. </math><math>\left. d{\mathit{\boldsymbol{I}}}_{p}\right) {\left( \boldsymbol{\Lambda }+k{\mathit{\boldsymbol{I}}}_{p}\right) }^{-1}{\mathit{\boldsymbol{X}}}^{\ast {\ast }^{'}}{\mathit{\boldsymbol{y}}}^{\ast }</math>
|}

We use <math display="inline">\mathrm{MSE}\,(\tilde{\mathit{\boldsymbol{\beta }}}(k,d),\mathit{\boldsymbol{\beta }})</math> to find the optimal values of <math display="inline">k</math> and <math display="inline">d</math>, where <math display="inline">\mathrm{MSE}\,(\tilde{\mathit{\boldsymbol{\beta }}}(k,d),\mathit{\boldsymbol{\beta }})</math> is the mean square error. Let <math display="inline">d</math> fixed, the optimal value of the <math display="inline">k</math> can be obtained by minimizing the following statement

{| class="formulaSCP" style="width: 100%; text-align: center;" 
|-
| <math>\mathrm{MSE}\,(\tilde{\mathit{\boldsymbol{\beta }}}(k,d),\mathit{\boldsymbol{\beta }})=</math><math>E\left[ (\tilde{\mathit{\boldsymbol{\beta }}}(k,d)-\mathit{\boldsymbol{\beta }}{)}^{'}(\tilde{\mathit{\boldsymbol{\beta }}}(k,d)-\right. </math><math>\left. \mathit{\boldsymbol{\beta }})\right]</math> 
|}

Notice that <math display="inline">\mathrm{MSE}\,(\tilde{\mathit{\boldsymbol{\beta }}}(k,d),\mathit{\boldsymbol{\beta }})=\mathrm{MSE}\,(\tilde{\gamma }(k,d),\gamma )=\mathrm{tr}\,[\mathrm{MSEM}\,(\tilde{\gamma }(k,d),\gamma )].</math> Therefore, getting <math display="inline">\frac{\partial \mathrm{MSE}\,(\tilde{\gamma }(k,d),\gamma )}{\partial k}=</math><math>0,</math> we obtain <math display="inline">k=\frac{{\sigma }^{2}\left( {\lambda }_{i}+d\right) -{\lambda }_{i}{\gamma }_{i}^{2}(1-d)}{{\gamma }_{i}^{2}\left( {\lambda }_{j}+1\right) }.</math> Since the optimal <math display="inline">k</math> depends on unknown <math display="inline">\gamma</math>  and <math display="inline">{\sigma }^{2},</math> then according Hoerl and Kennard [9] we can get the estimate of <math display="inline">k</math> by substituting <math display="inline">\tilde{\gamma }</math> and <math display="inline">{\tilde{\sigma }}^{2}</math> as follows:

{| class="formulaSCP" style="width: 100%; text-align: center;" 
|-
| 
{| style="text-align: center; margin:auto;" 
|-
| <math display="inline">\tilde{k}=\frac{{\tilde{\sigma }}^{2}\left( {\lambda }_{i}+d\right) -{\lambda }_{i}{\tilde{\gamma }}_{i}^{2}(1-d)}{{\tilde{\gamma }}_{i}^{2}\left( {\lambda }_{i}+1\right) }</math>
|}
| style="width: 5px;text-align: right;white-space: nowrap;" | (27)
|}

where <math display="inline">\tilde{\gamma }</math> and <math display="inline">{\tilde{\sigma }}^{2}</math> are the unbiased estimators <math display="inline">\mathit{\boldsymbol{\gamma }}</math> and <math display="inline">{\sigma }^{2}</math>. According to the estimator of <math display="inline">k,</math> which Kibria [25] and Hoerl and Kennard [9] proposed, the harmonic mean value of <math display="inline">k</math> in (27) is

Now, let <math display="inline">k</math> fixed, and we get the optimal value <math display="inline">d</math> by minimizing <math display="inline">\mathrm{MSE}\,(\tilde{\gamma }(k,d),\gamma )</math>. Therefore getting <math display="inline">\frac{\partial \mathrm{MSE}\,(\tilde{\gamma }(k,d),\gamma )}{\partial d}=</math><math>0,</math>

{| class="formulaSCP" style="width: 100%; text-align: center;" 
|-
| 
{| style="text-align: center; margin:auto;" 
|-
| <math display="inline">{\tilde{d}}_{opt}=\frac{\sum _{i=1}^{p}\frac{[\left( \left( k+1\right) {\lambda }_{i}+k\right) {\lambda }_{i}{\tilde{\gamma }}_{i}^{2}-\, {\lambda }_{i}^{2}{\tilde{\sigma }}^{2}\, ]}{[{(\, {\lambda }_{i}+k)}^{2}\ast {({\lambda }_{i}\, +1)}^{2}]}}{\sum _{i=1}^{p}\frac{[\left( {\tilde{\sigma }}^{2}\, +\, \, {\lambda }_{i}{\tilde{\gamma }}_{i}^{2}\right) {\lambda }_{i}]}{[{({\lambda }_{i}+k)}^{2}\ast {({\lambda }_{i}+1)}^{2}]}}</math>
|}
| style="width: 5px;text-align: right;white-space: nowrap;" | (28)
|}


Since <math display="inline">k</math> is always be positive, in this section we get the positive condition of the estimator in Eq. (27). For this purpose, we use the following theorem.

'''Theorem 5.1''' 

If <math display="inline">\tilde{d}>max\left\{ \frac{1-{\tilde{\sigma }}^{2}{\tilde{\gamma }}_{i}^{2}}{1+{\tilde{\sigma }}^{2}/\left( {\lambda }_{i}{\tilde{\gamma }}_{i}^{2}\right) }\right\}</math>,
for all <math display="inline">i,</math> then <math display="inline">{\tilde{k}}_{HM}</math> are always positive.

'''Proof.''' 

If <math display="inline">\frac{{\sigma }^{2}\left( {\lambda }_{i}+d\right) -{\lambda }_{i}{\gamma }_{i}^{2}(1-d)}{{\gamma }_{i}^{2}\left( {\lambda }_{i}+1\right) }>0</math>, then the values of <math display="inline">k</math> are positive. Since <math display="inline">{\gamma }_{i}^{2}\left( {\lambda }_{i}+1\right) >0</math> and <math display="inline">{\sigma }^{2}\left( {\lambda }_{i}+\right. </math><math>\left. d\right) -{\lambda }_{i}{\gamma }_{i}^{2}(1-d)</math> must be positive for all <math display="inline">i</math>. Then we get 
<math display="inline">d>\frac{1-{\sigma }^{2}/{\gamma }_{i}^{2}}{1+{\sigma }^{2}/\left( {\lambda }_{i}{\gamma }_{i}^{2}\right) }</math> and because depends on the unknown parameters <math display="inline">{\gamma }_{i}^{2}</math> and <math display="inline">{\sigma }^{2},</math> so their unbiased estimators are replaced. Therefore <math display="inline">{\tilde{k}}_{HM}</math> is always positive if <math display="inline">\tilde{d}</math> is selected as <math display="inline">\tilde{d}>max\left\{ \frac{1-{\tilde{\sigma }}^{2}{\tilde{\gamma }}_{i}^{2}}{1+{\tilde{\sigma }}^{2}/\left( {\lambda }_{j}{\tilde{\gamma }}_{i}^{2}\right) }\right\}</math>.

Note that <math display="inline">\frac{1-{\tilde{\sigma }}^{2}/{\gamma }_{i}^{2}}{1+{\tilde{\sigma }}^{2}/\left( {\lambda }_{i}{\tilde{\gamma }}_{i}^{2}\right) }</math> is always less than one and since <math display="inline">d</math> must be between zero and one, we consider the inequality <math display="inline">\tilde{d}>max\left\{ \frac{1-{\tilde{\sigma }}^{2}{\tilde{\gamma }}_{i}^{2}}{1+{\tilde{\sigma }}^{2}/\left( {\lambda }_{i}{\tilde{\gamma }}_{i}^{2}\right) }\right\}</math> as follows

{| class="formulaSCP" style="width: 100%; text-align: center;" 
|-
| 
{| style="text-align: center; margin:auto;" 
|-
| <math display="inline">max\left\{ \frac{1-{\tilde{\sigma }}^{2}{\tilde{\gamma }}_{i}^{2}}{1+{\tilde{\sigma }}^{2}/\left( {\lambda }_{i}{\tilde{\gamma }}_{i}^{2}\right) },o\right\} <\tilde{d}<1</math>
|}
| style="width: 5px;text-align: right;white-space: nowrap;" | (29)
|}


Since <math display="inline">{\tilde{d}}_{opt~}</math> in (28) depends on <math display="inline">k</math> and the estimators of <math display="inline">k</math> in <math display="inline">{\tilde{k}}_{HM}</math> depend on <math display="inline">d</math>, we consider an iterative method for these parameters by applying the following method. Step <math display="inline">1,</math> calculate <math display="inline">\tilde{d}</math> from Eq. (29). Step 2, calculate <math display="inline">{\tilde{k}}_{HM}</math> by using <math display="inline">\tilde{d}</math> in step 1 . Step <math display="inline">3,</math> calculate <math display="inline">{\tilde{d}}_{opt~}</math> from Eq. (28) by using the estimator <math display="inline">{\tilde{k}}_{HM}</math> in Step 2 . Step <math display="inline">4,</math> if <math display="inline">{\tilde{d}}_{opt~}</math> is not between zero and one use <math display="inline">{\tilde{d}}_{opt~}=</math><math>\tilde{d}</math>

==6. A simulation study==

In this section, we compare the performance of <math display="inline">\tilde{\mathit{\boldsymbol{\beta }}},\tilde{\mathit{\boldsymbol{\beta }}}(k,d),{\tilde{\mathit{\boldsymbol{\beta }}}}_{t}</math> and <math display="inline">{\tilde{\mathit{\boldsymbol{\beta }}}}_{r}(k,d)</math> with a simulation study. For this purpose, we calculate the estimated mean square error (EMSE) with various values of sample size, variance and degree of collinearity. Following McDonald and Galarneau [27], we are computed the fixed effects as

{| class="formulaSCP" style="width: 100%; text-align: center;" 
|-
| 
{| style="text-align: center; margin:auto;" 
|-
| <math display="inline">{X}_{ijc}={\left( 1-{\rho }^{2}\right) }^{1/2}{w}_{ijc}+\rho {w}_{ijp+l},{\, }i=</math><math>1,\ldots ,t,{\, }j=1,\ldots ,{n}_{i},{\, }c=1,\ldots ,p</math>
|}
| style="width: 5px;text-align: right;white-space: nowrap;" | (30)
|}


Where <math display="inline">{w}_{ijc}</math> independent standard normal are pseudo-random numbers and <math display="inline">{\rho }^{2}</math> is the correlation between any two fixed effects. Three different sets of <math display="inline">{\rho }^{2}</math> were considered as 0.75,0.85 and <math display="inline">0.95.</math> The <math display="inline">\mathit{\boldsymbol{Z}}</math> matrix is produced in a completely randomized design. Observation on responses are then determined by

{| class="formulaSCP" style="width: 100%; text-align: center;" 
|-
| 
{| style="text-align: center; margin:auto;" 
|-
| <math display="inline">{y}_{ij}={\beta }_{1}{x}_{ij1}+\ldots +{\beta }_{p}{x}_{ijp}+</math><math>{u}_{i1}{z}_{ij1}+\ldots +{u}_{iq}{z}_{ijq}+{\epsilon }_{ij},{\, }i=1,\ldots ,t,j=</math><math>1,\ldots ,{n}_{i}</math>
|}
| style="width: 5px;text-align: right;white-space: nowrap;" | (31)
|}


We consider two designs that in the first design <math display="inline">{n}_{i}=</math><math>3</math> and in the second design <math display="inline">{n}_{i}=7</math>. Also, the same value <math display="inline">t=</math><math>9,p=4</math> and <math display="inline">q=9</math> are taken in both designs. Following Ozcale and Can (2017) “The <math display="inline">\mathit{\boldsymbol{\beta }}</math> vector was chosen as the eigenvector corresponding to the largest eigenvalue of the <math display="inline">{\boldsymbol{X}}^{'}{\mathit{\boldsymbol{H}}}^{-1}\mathit{\boldsymbol{X}}</math> matrix”. The variances matrix of random effects <math display="inline">{u}_{i}</math> and <math display="inline">{\epsilon }_{ij}</math> are <math display="inline">\mathit{\boldsymbol{G}}=</math><math>{\sigma }_{1}^{2}{\mathit{\boldsymbol{I}}}_{q}</math> and <math display="inline">\mathit{\boldsymbol{W}}=</math><math>{\sigma }^{2}{\mathit{\boldsymbol{I}}}_{a}</math><br/>respectively. They <math display="inline">{u}_{i}</math> are generated from the normal distribution <math display="inline">N(0,G)</math>. We are considered <math display="inline">{\sigma }^{2}=</math><math>0.5,1</math> and <math display="inline">{\sigma }_{1}^{2}=0.5,1</math>.The trial was replicated 1000 times by generating <math display="inline">{u}_{i}</math> and <math display="inline">{\epsilon }_{ij}.</math> For each simulated data set derived <math display="inline">{\tilde{k}}_{HM}</math> and <math display="inline">{\tilde{d}}_{opt~},</math> and then the estimated mean squared error (EMSE) calculated as calculated the relative mean square (RMSE) as
{| class="formulaSCP" style="width: 100%; text-align: center;" 
|-
| <math>\mathrm{RMSE}\,\left( \tilde{\mathit{\boldsymbol{\beta }}}:{\tilde{\mathit{\boldsymbol{\beta }}}}^{\ast }\right) =</math><math>\frac{\mathrm{EMSE}\,(\tilde{\mathit{\boldsymbol{\beta }}})}{\mathrm{EMSE}\,\left( {\tilde{\mathit{\boldsymbol{\beta }}}}^{\ast }\right) }<br/></math>
|}
when <math display="inline">RMSE</math> is greater than one, it indicates that the estimator <math display="inline">{\tilde{\mathit{\boldsymbol{\beta }}}}^{\ast }</math> superior to the estimator <math display="inline">\tilde{\mathit{\boldsymbol{\beta }}}</math>. For the stochastic linear restriction <math display="inline">\mathit{\boldsymbol{r}}=</math><math>\mathit{\boldsymbol{R\beta }}+\Phi ,</math> the matrix <math display="inline">\mathit{\boldsymbol{R}}</math> is <math display="inline">m\times p</math> and generated from the normal distribution <math display="inline">N(0,1)</math> and the matrix <math display="inline">\Phi</math>  is generated from the normal distribution <math display="inline">N(0,\mathit{\boldsymbol{V}})</math> where <math display="inline">\mathit{\boldsymbol{V}}</math> is taken as <math display="inline">=</math><math>\mathrm{diag}\,\left( {\sigma }^{2}{\mathit{\boldsymbol{I}}}_{m}\right.</math>  ) with <math display="inline">m=</math><math>2</math>. In tables 1 , we obtain the values of EMSE and RMSE for <math display="inline">\tilde{\mathit{\boldsymbol{\beta }}},\tilde{\mathit{\boldsymbol{\beta }}}(k,d),{\tilde{\mathit{\boldsymbol{\beta }}}}_{r}</math> and <math display="inline">{\tilde{\mathit{\boldsymbol{\beta }}}}_{r}(k,d).</math> We have the following results for Table 1: 

(i) In the whole table, the EMSE values of <math display="inline">\tilde{\mathit{\boldsymbol{\beta }}}(k,d)</math> is less than <math display="inline">\tilde{\mathit{\boldsymbol{\beta }}}</math>. Also, the EMSE values of <math display="inline">{\tilde{\mathit{\boldsymbol{\beta }}}}_{r}(k,d)</math> is less than <math display="inline">{\tilde{\mathit{\boldsymbol{\beta }}}}_{r}</math>. In general, the EMSE values of <math display="inline">{\tilde{\mathit{\boldsymbol{\beta }}}}_{r}(k,d)</math> is less than all estimators. 

(ii) As <math display="inline">{\rho }^{2}</math> and <math display="inline">{\sigma }^{2}</math> increase, the EMSE values of the estimators increase.

(iii) As <math display="inline">{\rho }^{2}</math> increases, difference between the EMSE values of the two parameter estimators and the EMSE values of the best linear unbiased estimators increase. This implies an increase in the improvement of the two-parameter estimators.

Table 1. Estimated <math display="inline">MSE</math> and SMSE values with <math display="inline">{\tilde{k}}_{HM},{\tilde{d}}_{opt~}</math> and <math display="inline">t=</math><math>9</math>

{| style="width: 100%;border-collapse: collapse;" 
|-
|  style="border: 1pt solid black;vertical-align: top;"|p=0.75
|  colspan='2'  style="border: 1pt solid black;vertical-align: top;"|<math>\left( {\sigma }^{2},{\sigma }_{1}^{2}\right) =(0.5,0.5)</math>
|  colspan='2'  style="border: 1pt solid black;vertical-align: top;"|<math>\left( {\sigma }^{2},{\sigma }_{1}^{2}\right) =(1,1)</math>
|-
|  style="border: 1pt solid black;vertical-align: top;"|ni
|  style="border: 1pt solid black;vertical-align: top;"|3
|  style="border: 1pt solid black;vertical-align: top;"|7
|  style="border: 1pt solid black;vertical-align: top;"|3
|  style="border: 1pt solid black;vertical-align: top;"|7
|-
|  style="border: 1pt solid black;vertical-align: top;"|<math>\mathrm{EMSE}\,(\tilde{\mathit{\boldsymbol{\beta }}})</math>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0001526       </span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">7.3974e-05</span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0003053         </span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0001479</span>
|-
|  style="border: 1pt solid black;vertical-align: top;"|<math>\mathrm{EMSE}\,\left( {\tilde{{\mathit{\boldsymbol{\beta }}}_{\mathit{\boldsymbol{r}}}}}_{\, }\right)</math> 
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0001461       </span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">7.1668e-05</span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0002923         </span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0001433</span>
|-
|  style="border: 1pt solid black;vertical-align: top;"|<math>\mathrm{EMSE}\,(\tilde{\mathit{\boldsymbol{\beta }}}(k,d))</math>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0001032       </span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">6.9166e-05</span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0001912          </span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0001332</span>
|-
|  style="border: 1pt solid black;vertical-align: top;"|<math>\mathrm{EMSE}\,\left( {\tilde{\mathit{\boldsymbol{\beta }}}}_{r}(k,d)\right)</math> 
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">9.9335e-05      </span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">6.7089e-05</span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0001845         </span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0001293</span>
|-
|  style="border: 1pt solid black;vertical-align: top;"|<math>\mathrm{RMSE}\,(\tilde{\mathit{\boldsymbol{\beta }}}:\tilde{\mathit{\boldsymbol{\beta }}}(k,d))</math>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">1.4795             </span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">1.0695</span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">1.5965                </span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">1.1104</span>
|-
|  style="border: 1pt solid black;vertical-align: top;"|<math>\mathrm{RMSE}\,\left( {\tilde{\mathit{\boldsymbol{\beta }}}}_{r}:{\tilde{\mathit{\boldsymbol{\beta }}}}_{c}(k,d)\right)</math> 
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">1.4716             </span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">1.0682</span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">1.5845</span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">1.1083</span>
|-
|  style="border: 1pt solid black;vertical-align: top;"|<math>\mathrm{RMSE}\,\left( \tilde{\mathit{\boldsymbol{\beta }}}(k,d):{\tilde{\mathit{\boldsymbol{\beta }}}}_{\mathit{\boldsymbol{c}}}(k,d)\right)</math> 
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">1.0389             </span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">1.0309</span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">1.0363                 </span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">1.0301</span>
|-
|  style="border: 1pt solid black;vertical-align: top;"|p=0.85
|  colspan='2'  style="border: 1pt solid black;vertical-align: top;"|<math>\left( {\sigma }^{2},{\sigma }_{1}^{2}\right) =(0.5,0.5)</math>
|  colspan='2'  style="border: 1pt solid black;vertical-align: top;"|<math>\left( {\sigma }^{2},{\sigma }_{1}^{2}\right) =(1,1)</math>
|-
|  style="border: 1pt solid black;vertical-align: top;"|ni
|  style="border: 1pt solid black;vertical-align: top;"|3
|  style="border: 1pt solid black;vertical-align: top;"|7
|  style="border: 1pt solid black;vertical-align: top;"|3
|  style="border: 1pt solid black;vertical-align: top;"|7
|-
|  style="border: 1pt solid black;vertical-align: top;"|<math>\mathrm{EMSE}\,(\tilde{\mathit{\boldsymbol{\beta }}})</math>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0002198</span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0003460</span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0004396        </span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0002387</span>
|-
|  style="border: 1pt solid black;vertical-align: top;"|<math>\mathrm{EMSE}\,\left( {\tilde{{\mathit{\boldsymbol{\beta }}}_{\mathit{\boldsymbol{r}}}}}_{\, }\right)</math> 
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0002076         </span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0001134</span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0004153         </span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0002269</span>
|-
|  style="border: 1pt solid black;vertical-align: top;"|<math>\mathrm{EMSE}\,(\tilde{\mathit{\boldsymbol{\beta }}}(k,d))</math>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0001332         </span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0001045</span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0002562         </span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0002111</span>
|-
|  style="border: 1pt solid black;vertical-align: top;"|<math>\mathrm{EMSE}\,\left( {\tilde{\mathit{\boldsymbol{\beta }}}}_{r}(k,d)\right)</math> 
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0001277         </span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0002460</span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0002459        </span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0002014</span>
|-
|  style="border: 1pt solid black;vertical-align: top;"|<math>\mathrm{RMSE}\,(\tilde{\mathit{\boldsymbol{\beta }}}:\tilde{\mathit{\boldsymbol{\beta }}}(k,d))</math>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">1.6495                </span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">1.1414</span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">1.7156             </span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">1.1308</span>
|-
|  style="border: 1pt solid black;vertical-align: top;"|<math>\mathrm{RMSE}\,\left( {\tilde{\mathit{\boldsymbol{\beta }}}}_{r}:{\tilde{\mathit{\boldsymbol{\beta }}}}_{c}(k,d)\right)</math> 
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">1.6263                </span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">1.1373</span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">1.6889             </span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">1.1266</span>
|-
|  style="border: 1pt solid black;vertical-align: top;"|<math>\mathrm{RMSE}\,\left( \tilde{\mathit{\boldsymbol{\beta }}}(k,d):{\tilde{\mathit{\boldsymbol{\beta }}}}_{\mathit{\boldsymbol{c}}}(k,d)\right)</math> 
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">1.0430                </span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">1.1219</span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">1.0418</span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">1.0481</span>
|-
|  style="border: 1pt solid black;vertical-align: top;"|p=0.95
|  colspan='2'  style="border: 1pt solid black;vertical-align: top;"|<math>\left( {\sigma }^{2},{\sigma }_{1}^{2}\right) =(0.5,0.5)</math>
|  colspan='2'  style="border: 1pt solid black;vertical-align: top;"|<math>\left( {\sigma }^{2},{\sigma }_{1}^{2}\right) =(1,1)</math>
|-
|  style="border: 1pt solid black;vertical-align: top;"|ni
|  style="border: 1pt solid black;vertical-align: top;"|3
|  style="border: 1pt solid black;vertical-align: top;"|7
|  style="border: 1pt solid black;vertical-align: top;"|3
|  style="border: 1pt solid black;vertical-align: top;"|7
|-
|  style="border: 1pt solid black;vertical-align: top;"|<math>\mathrm{EMSE}\,(\tilde{\mathit{\boldsymbol{\beta }}})</math>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0005729</span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0003460</span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0011459          </span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0006920</span>
|-
|  style="border: 1pt solid black;vertical-align: top;"|<math>\mathrm{EMSE}\,\left( {\tilde{{\mathit{\boldsymbol{\beta }}}_{\mathit{\boldsymbol{r}}}}}_{\, }\right)</math> 
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0005033        </span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0003044</span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0010066          </span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0006088</span>
|-
|  style="border: 1pt solid black;vertical-align: top;"|<math>\mathrm{EMSE}\,(\tilde{\mathit{\boldsymbol{\beta }}}(k,d))</math>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0002762        </span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0002760</span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0005201           </span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0005272</span>
|-
|  style="border: 1pt solid black;vertical-align: top;"|<math>\mathrm{EMSE}\,\left( {\tilde{\mathit{\boldsymbol{\beta }}}}_{r}(k,d)\right)</math> 
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0002578        </span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0002460</span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0004927          </span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">0.0004716</span>


|-
|  style="border: 1pt solid black;vertical-align: top;"|<math>\mathrm{RMSE}\,(\tilde{\mathit{\boldsymbol{\beta }}}:\tilde{\mathit{\boldsymbol{\beta }}}(k,d))</math>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">2.0743              </span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">1.2533</span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">2.2030                </span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">1.3125</span>
|-
|  style="border: 1pt solid black;vertical-align: top;"|<math>\mathrm{RMSE}\,\left( {\tilde{\mathit{\boldsymbol{\beta }}}}_{r}:{\tilde{\mathit{\boldsymbol{\beta }}}}_{c}(k,d)\right)</math> 
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">1.9524              </span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">1.2369</span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">2.0429                </span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">1.2908</span>
|-
|  style="border: 1pt solid black;vertical-align: top;"|<math>\mathrm{RMSE}\,\left( \tilde{\mathit{\boldsymbol{\beta }}}(k,d):{\tilde{\mathit{\boldsymbol{\beta }}}}_{\mathit{\boldsymbol{c}}}(k,d)\right)</math> 
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">1.0713               </span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">1.1219</span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">1.0556                </span>
|  style="border: 1pt solid black;vertical-align: top;"|<span style="text-align: center; font-size: 75%;">1.1178</span>
|}


==7. Real data analysis==

We consider a data set, which is known as the Egyptian pottery data to show the behavior of the new Restricted and Unrestricted Two-Parameter Estimators. This data set arises from an extensive archaeological survey of pottery production and distribution in the ancient Egyptian city of Al-Amarna. The data consist of measurements of chemical contents (mineral elements) made on many samples of pottery using two different techniques, NAA and ICP (see Smith et al. [30] for description of techniques). The set of pottery was collected from different locations around the city. We fit the data set by linear mixed model as <math display="inline">\mathit{\boldsymbol{y}}=</math><math>\mathit{\boldsymbol{X\beta }}+\mathit{\boldsymbol{Zu}}+\mathit{\boldsymbol{\epsilon }},</math> where <math display="inline">\mathit{\boldsymbol{y}}</math> is <math display="inline">159\times 1</math> vector of response variables, <math display="inline">\mathit{\boldsymbol{X}}</math> and <math display="inline">\mathit{\boldsymbol{Z}}</math> which are regression matrix with dimensions <math display="inline">159\times 6</math> and <math display="inline">159\times 25</math> respectively. First, we are estimated the variance components by consider <math display="inline">{\sigma }_{1}^{2}=</math><math>0.5</math> and <math display="inline">{\sigma }^{2}=0.5.</math> Then, by calculating the eigenvalues of <math display="inline">\mathit{\boldsymbol{X}}{\mathit{\boldsymbol{H}}}^{-1}\mathit{\boldsymbol{X}},</math> the condition number 8322860 is obtained, which indicate severe multicollinearity. We considered the stochastic linear restrictions as <math display="inline">\mathit{\boldsymbol{r}}=</math><math>\mathit{\boldsymbol{R\beta }}+\Phi ,\Phi \sim N\left( 0,{\sigma }^{2}{\mathit{\boldsymbol{I}}}_{3}\right)</math>  and selected 3 available data in the previous sections to the Egyptian pottery data. <math display="inline">{\tilde{k}}_{HM}</math> and <math display="inline">{\tilde{d}}_{opt}</math> are obtained using the iterative method introduced at the end of section 5,0.348 and 0.373 respectively. In Table 2 the estimated <math display="inline">MSE</math> values of the estimators are obtained by replacing in the corresponding theoretical MSE equations. We can see the estimated MSE values of <math display="inline">\tilde{\mathit{\boldsymbol{\beta }}}(k,d)</math> is less than <math display="inline">\tilde{\mathit{\boldsymbol{\beta }}}</math>. Also, the estimated MSE values of <math display="inline">{\tilde{\mathit{\boldsymbol{\beta }}}}_{c}(k,d)</math> is less than <math display="inline">{\tilde{\mathit{\boldsymbol{\beta }}}}_{r}</math>. In general, the estimated MSE values of <math display="inline">{\tilde{\mathit{\boldsymbol{\beta }}}}_{r}(k,d)</math> is less than all estimators. So, we conclude that the stochastic restricted two parameter estimator performs better than the other estimators. Note that in the results obtained for this data, all eigenvalues of <math display="inline">{\Delta }_{1}</math> and <math display="inline">{\Delta }_{2}</math> are positive and the condition of Theorem 4.1 and Theorem 4.2 are true. In Figure 1 , a plot of the estimated MSE values of <math display="inline">\tilde{\mathit{\boldsymbol{\beta }}}</math> and <math display="inline">\tilde{\mathit{\boldsymbol{\beta }}}(k,d)</math> against <math display="inline">k</math> in the interval [0,2] with fixed <math display="inline">{\tilde{d}}_{opt~}=</math><math>0.373</math> is drawn. Because <math display="inline">\tilde{\beta }</math> is not dependent on <math display="inline">k</math>, its estimated <math display="inline">MSE</math> value is the same for all <math display="inline">k</math> values. It is obvious that estimated <math display="inline">MSE</math> values of <math display="inline">\tilde{\mathit{\boldsymbol{\beta }}}(k,d)</math> is always less than <math display="inline">\tilde{\mathit{\boldsymbol{\beta }}}</math>. Altogether, it is obvious that the two parameter estimators can perform better than the <math display="inline">\tilde{\mathit{\boldsymbol{\beta }}}</math> in MSEM criterion under conditions.

<div class="center" style="width: auto; margin-left: auto; margin-right: auto;">
Table 2. Estimated MSE values of the proposed estimators.</div>

{| style="width: 100%;border-collapse: collapse;" 
|-
|  style="border: 1pt solid black;vertical-align: top;"|
|  style="border: 1pt solid black;"|<math>\tilde{\mathit{\boldsymbol{\beta }}}{\, }{\, }{\, }</math>


|  style="border: 1pt solid black;"|<math>{\tilde{\mathit{\boldsymbol{\beta }}}}_{r}</math>


|  style="border: 1pt solid black;"|<math>\tilde{\mathit{\boldsymbol{\beta }}}(k,d)</math>


|  style="border: 1pt solid black;"|<math>{\tilde{\mathit{\boldsymbol{\beta }}}}_{r}(k,d)</math>


|-
|  style="border: 1pt solid black;"|EMSE
|  style="border: 1pt solid black;"|1.216069
|  style="border: 1pt solid black;"|1.201379
|  style="border: 1pt solid black;"|0.1544953
|  style="border: 1pt solid black;"|0.1541745
|}


<div class="center" style="width: auto; margin-left: auto; margin-right: auto;">
<span style="text-align: center; font-size: 75%;"> [[Image:Review_312425094190-image1.png|276px]] </span></div>

<div class="center" style="width: auto; margin-left: auto; margin-right: auto;">
Figure <math display="inline">1.</math> The estimated mean square error values of the estimators versus <math display="inline">k</math> with <math display="inline">{\tilde{d}}_{of~}</math></div>

==8. Conclusion==

In this article, we proposed the two parameter estimator and the stochastic restricted two parameter estimator to overcome the effects of the multicollinearity problem in linear mixed models. We also obtained estimates of variance parameters and then using the mean squared error matrix sense made comparisons between the proposed estimators and some other estimators. Finally, we proposed methods for estimating biasing parameters and provided a simulation study and a data example to illustrate performance of new estimators.

==Disclosure statement==

No potential conflict of interest was reported by the authors..

==Funding==

The research was supported by the Payame Noor University.

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